Objective:To observe the clinical effect of Shuganyishen prescriptipn combined with western therapy on estrogen-dependent advanced breast cancer

and to investigate the mechanism from the angle of affecting hormone.Method:A total of 38 patients with visceral or brain metastasis were administered with Shuganyishen prescription combined with western treatment.shuganyishen prescription's dosage was 200 mL

twice a day

and west medicine treament regimen was administered by NCCN guideline.Results:The median survival of recurrence(MSR) was 34.08 months

time to progress was 9.6 months.one and two year survival rates were 92%

62.5% respectively

mean and median survival times with liver metastasis were 20.48 months and 20 months respectively.Mean and median survival times with lung metastasis were 44.47 months and 52 months respectively.Mean and median survival times with both liver and lung metastasis were 44.47 months and 52 months respectively.Mean and median survival times with both liver and lung metasis were 8 months and 11 months respectively.It decreased E2 and

improved follicle-stimulating hormone(FSH).The remission rate of red flash symptom was 70.1%.Conclusion:Shuganyishen prescription had good clinical effect to estrogen-dependent advanced breast cancer

and relieved red flash symptom.The mechanism might be that the prescription inhibited E2 and the phytoestrogens in the herbs had effect on ERβ.