Determination of Emodin,Chrysophanol in Yankening Tablets by HPLC

ZHANG Da-jun; WANG Zhao-hua; LI Xiang-yu

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Determination of Emodin,Chrysophanol in Yankening Tablets by HPLC

更新时间：2024-01-04

- Determination of Emodin,Chrysophanol in Yankening Tablets by HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 4, Pages: 17-19(2009)
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- Published：2009
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ZHANG Da-jun, WANG Zhao-hua, LI Xiang-yu. Determination of Emodin,Chrysophanol in Yankening Tablets by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(4): 17-19.
DOI：

ZHANG Da-jun, WANG Zhao-hua, LI Xiang-yu. Determination of Emodin,Chrysophanol in Yankening Tablets by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(4): 17-19. DOI：

摘要

目的:应用高效液相色谱法测定炎可宁片中大黄素

大黄酚的含量。方法:采用Shim-pack-C18柱(5μm

150×4.6mm)

以甲醇-0.1%磷酸(85∶15)为流动相

检测波长254nm。结果:大黄素、大黄酚线性范围分别为(0.016128～0.08064μg

r=0.9997;0.03248～0.1624μg

r=0.9998大黄素

大黄酚的回收率分别为97.88%

RSD=1.64%;97.93%

RDS=0.71%。结论:该方法用于测定炎可宁片中大黄素、大黄酚的含量

具有简便、准确、灵敏的特点

可作为该制剂质量控制的制标。

Abstract

Objective:To determine the content of Emodin

Chrysophanol in Yankening tablets by high performance liquid chromatography.Methods:The determination was carried out on a Shim-pack-C18 column(5 μm

150 mm×4.6 mm)eluted with the mobile phase of methanol water containing 0.1% phosphoric acid(85∶15).The detection wavelength was 254 nm.Results:A good linear relationship between the peak areas and the injection amounts was found for emodin within(0.016 128～0.080 64)μg

with a correlation coefficient of 0.999 7

for chrysophanol within(0.032 48～0.162 4)μg

with a correlation coefficient of(0.999 8).The average recovery of Emodin was 97.88%(RSD 1.64%)

and of Chrysophanol was 97.93%(RSD 0.71%).Conclusion: The method is simple

accurate

sensitive and can be applied to the quality control of the preparation.

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