Optimum of  Gel Sustained-release Matrix Tablets by Orthogonal Design

LIU Gui-hua; XING Jian-guo; XUE Gui-peng; WANG Xin-chun; DANG Xue-liang; ZHANG Ya-hui

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Optimum of Gel Sustained-release Matrix Tablets by Orthogonal Design

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- Optimum of Gel Sustained-release Matrix Tablets by Orthogonal Design
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 17-19(2010)
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- Published：2010
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LIU Gui-hua, XING Jian-guo, XUE Gui-peng, et al. Optimum of Gel Sustained-release Matrix Tablets by Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 17-19.
DOI：

LIU Gui-hua, XING Jian-guo, XUE Gui-peng, et al. Optimum of Gel Sustained-release Matrix Tablets by Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 17-19. DOI：

摘要

目的: 优化天山雪莲缓释片制备工艺并探讨药物释药机制。方法: 采用正交实验法

以绿原酸、芦丁累积释放度综合评分K值为指标

优选HPMC用量、淀粉:乳糖的比例和微晶纤维素用量

采用数学模型拟合释放曲线。结果: 最佳处方为HPMC K15M用量为17%

淀粉:乳糖为2 ∶1

MCC用量为1%;优化后的处方释放模型符合Higuchi方程。结论: 天山雪莲缓释片体外释放性能良好

为处方设计合理性提供了依据。

Abstract

Objective: To optimize the Saussurea involucrate sustained-release tablets and to study the release mechanism of the mainactive composition of Saussurea involucrate. Method: The amount of HPMC and MCC

the ratio of starch with lactose were screened by using method of orthogonal design and by selecting cumulative release of chlorogenic acid and rutin as index. Mathematic models were used to imitate the drug release. Result: The optimum formula was as follows the amount of HPMC K15m was 17%

the ratio of starch with lactose was 2 ∶1 and the amount of MCC was 1%. The release of chlorogenic acid and rutin was conformed to Higuchi equation. Conclusion: The release of two mainactive composition of Saussurea involucrate could be well described in vitro and give good foundation for rationality of formula design.

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Related Author

LIU Gui-hua1

XING Jian-guo2

XUE Gui-peng2

WANG Xin-chun1

DANG Xue-liang1

ZHANG Ya-hui1

HE Xia-qiu

HE Jian-hua

Related Institution

School of Pharmacy,Shihezi University

Xinjiang Institute of Meteria

The First Affiliated Hospital of Medical College,Shihezi University

Dongguan Hospital of Traditional Chinese Medicine

School of Pharmacy,Shihezi University

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