Analgesic,Anti-inflammatory Effects and Chemical Constituents of Ethanol Extract from Shufu
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Analgesic,Anti-inflammatory Effects and Chemical Constituents of Ethanol Extract from Shufu
Chinese Journal of Experimental Traditional Medical FormulaeVol. 14, Issue 11, Pages: 74-76(2008)
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Published:2008
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LI Ning, KUANG Yan-wei, CHEN Ming-you, et al. Analgesic,Anti-inflammatory Effects and Chemical Constituents of Ethanol Extract from Shufu[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(11): 74-76.
DOI:
LI Ning, KUANG Yan-wei, CHEN Ming-you, et al. Analgesic,Anti-inflammatory Effects and Chemical Constituents of Ethanol Extract from Shufu[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(11): 74-76.DOI:
Analgesic,Anti-inflammatory Effects and Chemical Constituents of Ethanol Extract from Shufu
anti-inflammatory effects and the chemical constituents of alcohol extract of Shufu.(AVA) Methods:The analgesic effect of AVA were tested by counting body twisting induced by HAc in mice and the anti-inflammatory effects of AVA were tested by using the Colorimetric COX Inhibitor Screening Assay.The constituents were isolated and purified by chromatographic methods.Their structures were identified by physicochemical properties and spectral analysis.Results:AVA could delay the writhing time and reduce the writhing times in mice. AVA could inhibit the COX-1 and COX-2 enzymes activitres.Seven compounds were isolated and the stuctures were identified as β-Sitosterol
cholesterol
ergosterol
7-OH cholesterol
7β-OH cholesterol
octadecanoic acid and 9-octadecenoic acid.Conclusions:AVA has obvious analgesic and anti-inflammatory effects.
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Related Institution
School of Basic Medicine, Chengdu University of Traditional Chinese Medicine
Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Jiangxi University of Chinese Medicine
Key Laboratory of Natural Medicine Pharmacology of Yunnan Province, School of Pharmacy, Kunming Medical University
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