Effects of Four Active Components from Traditional Herbs on the Proliferation and Collagen Synthesis of Rat Vascular Adventitial Fibroblasts Induced by Angiotensin Ⅱ

LU Yan-min; LI Lan-fang; Huo Hai-ru; TAN Yu-qing

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Effects of Four Active Components from Traditional Herbs on the Proliferation and Collagen Synthesis of Rat Vascular Adventitial Fibroblasts Induced by Angiotensin Ⅱ

更新时间：2024-01-04

- Effects of Four Active Components from Traditional Herbs on the Proliferation and Collagen Synthesis of Rat Vascular Adventitial Fibroblasts Induced by Angiotensin Ⅱ
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 11, Pages: 68-70(2008)
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- Published：2008
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LU Yan-min, LI Lan-fang, Huo Hai-ru, et al. Effects of Four Active Components from Traditional Herbs on the Proliferation and Collagen Synthesis of Rat Vascular Adventitial Fibroblasts Induced by Angiotensin Ⅱ[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(11): 68-70.
DOI：

LU Yan-min, LI Lan-fang, Huo Hai-ru, et al. Effects of Four Active Components from Traditional Herbs on the Proliferation and Collagen Synthesis of Rat Vascular Adventitial Fibroblasts Induced by Angiotensin Ⅱ[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(11): 68-70. DOI：

摘要

目的:体外观察盐酸川芎嗪、葛根素、丹参酮ⅡA、丹皮酚对血管紧张素Ⅱ(ANG-Ⅱ)诱导的大鼠血管外膜成纤维细胞(VAF)的增殖及胶原蛋白合成的影响。方法:MTT法检测细胞增殖活性;羟脯氨酸比色法测定细胞培养上清液中胶原蛋白含量。结果:4种中药成分能够显著降低ANG-Ⅱ诱导的VAF增殖及细胞培养上清液中羟脯氨酸含量。结论:盐酸川芎嗪、葛根素、丹参酮ⅡA、丹皮酚能够抑制ANG-Ⅱ诱导的VAF增殖和胶原合成。

Abstract

Objective:The purpose of this study is to explore the effects of four active components from traditional herbs including tetramethylpyrazine

puerarin

tanshinone ⅡA and paeonol on the proliferation and collagen synthesis of vascular adventitial fibroblasts(VAF) induced by angiotensin Ⅱ(ANG-Ⅱ).Methods:MTT assay was used for observing cell proliferation

and hydroxyproline chromatometry was used for detecting collagen synthesis.Results:These four herbs significantly decreased the proliferation rate and the amount of hydroxyproline of VAF components from respectively.Conclusions:Tetramethylpyrazine

puerarin

tanshinone ⅡA and paeonol could decrease the proliferation and collagen synthesis of VAF.

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Related Author

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Related Institution

Clinical College of Chinese Medicine， Gansu University of Chinese Medicine

Gansu Provincial Hospital of Traditional Chinese Medicine

School of Pharmacy，Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and Application， Nanjing University of Chinese Medicine

The First Clinical Medical College，Nanjing University of Chinese Medicine

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