Preparation of Osmotic Pump Controlled Release Tablets of Panax Notoginoside

DUAN Hong-yun; ZHANG Sheng; ZHU Peng-fei; LIU Yu-feng; CHEN Li-jiang

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Preparation of Osmotic Pump Controlled Release Tablets of Panax Notoginoside

更新时间：2024-09-23

- Preparation of Osmotic Pump Controlled Release Tablets of Panax Notoginoside
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 6-10(2010)
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- Published：2010
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DUAN Hong-yun, ZHANG Sheng, ZHU Peng-fei, et al. Preparation of Osmotic Pump Controlled Release Tablets of Panax Notoginoside[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 6-10.
DOI：

DUAN Hong-yun, ZHANG Sheng, ZHU Peng-fei, et al. Preparation of Osmotic Pump Controlled Release Tablets of Panax Notoginoside[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 6-10. DOI：

摘要

目的: 制备三七总皂苷渗透泵控释片。方法: 考察各因素对药物释放的影响

采用正交试验优化处方。结果: 包衣膜的增重和包衣液中PEG400用量对三七总皂苷渗透泵控释片的体外释药行为有显著影响

得到最佳处方为:衣膜增重5％

PEG400的用量为90％

NaCl的用量为30％。结论: 通过处方优化可将三七总皂苷制成释药恒速、较完全的渗透泵控释片。

Abstract

Objective: To prepare osmotic pump controlled release tablets of panax notoginoside. Method: The factor influencing the drug release was investigated by the single factor; orthogonal design was used to get the quantitative relationship among the release. Result: The drug release profile in vitro was influenced by membrane weight and the amount of PEG400. The optimum formulation was: PEG400 90％

NaCl 30％

and the membrane weight 5％(as the percent of the core). Conclusion: The panax notoginoside osmotic pump tablets are attainable by constant speed delivery.

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Related Author

DUAN Hong-yun1

ZHANG Sheng2

ZHU Peng-fei3

LIU Yu-feng1

CHEN Li-jiang1

HE Xia-qiu

HE Jian-hua

MA Yan-qiong

Related Institution

School of Chinese Medicine,Capital Medical University

Liaoning Institute of Medicine

College of Pharmacy,Liaoning University

Dongguan Hospital of Traditional Chinese Medicine

The Xinjiang Institute of Materia Medic

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