The Effects of Houshiheisan on Activeness of Na-K-ATPase and NOS in Cerebral Tissue of Middle Cerebral Artery Occlusion Model in Rat

ZHANG Qiu-xia; ZHAO Hui

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The Effects of Houshiheisan on Activeness of Na-K-ATPase and NOS in Cerebral Tissue of Middle Cerebral Artery Occlusion Model in Rat

更新时间：2024-01-04

- The Effects of Houshiheisan on Activeness of Na-K-ATPase and NOS in Cerebral Tissue of Middle Cerebral Artery Occlusion Model in Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 7, Pages: 31-33(2008)
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- Published：2008
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ZHANG Qiu-xia, ZHAO Hui. The Effects of Houshiheisan on Activeness of Na-K-ATPase and NOS in Cerebral Tissue of Middle Cerebral Artery Occlusion Model in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(7): 31-33.
DOI：

ZHANG Qiu-xia, ZHAO Hui. The Effects of Houshiheisan on Activeness of Na-K-ATPase and NOS in Cerebral Tissue of Middle Cerebral Artery Occlusion Model in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(7): 31-33. DOI：

摘要

目的:观察侯氏黑散对大脑中动脉闭塞模型大鼠缺血脑组织Na+-K+-ATP酶、一氧化氮合酶(NOS)活性以及诱导型一氧化氮合酶(iNOS)的影响。方法:采用线栓法复制大鼠大脑中动脉闭塞模型

利用比色法观察侯氏黑散对大鼠缺血脑组织Na+-K+-ATP酶、NOS、iNOS活性的影响。结果:与模型组比较

侯氏黑散组大

中剂量组缺血脑组织Na+-K+-ATP酶活性显著提高(P<0.05)。侯氏黑散大

中

小剂量组NOS、iNOS的活性明显降低(P<0.05)。结论:侯氏黑散可能是通过提高脑组织Na+-K+-ATP酶活性和降低NOS、iNOS的活性保护和修复缺血性脑损伤。

Abstract

Objective:To observe the effects of Houshiheisan on activities of Na+-K+-ATPase

NOS and iNOS in cerebral tissue of middle cerebral artery occlusion model in rat.Methods: Middle cerebral artery occlusion model was replicated by string ligation.Using behavioral test

the neurological deficiency of each group after operation was evaluated.The change in Na+-K+-ATPase

NOS and iNOS was detected by colorimetry.We observed the effects of Houshiheisan on activities of Na+-K+-ATPase

NOS and iNOS in cerebral tissue of middle cerebral artery occlusion model.Results: In comparison with model group

Houshiheisan can increase the activities of Na+-K+-ATPase in ischemic tissue of brain with the large or middle dose.Moreover Houshiheisan decreased activities of NOS and iNOS in ischemic tissue of brain with the large

middle and lower dose.Conclusions:Houshiheisan may increase the activities of Na+-K+-ATPase and decrease activities of NOS and iNOS for protecting the ischemia tissue.

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