Preliminary Studies on Antipyretic Activity and Its Mechanisms of Total Coumarins from Artemisia annua

GONG Yu-jing1; YAN Han1; LI Ai-yuan2; ZHAO Yi2; LIN Qi-yun2; Li Cang-hai1

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Preliminary Studies on Antipyretic Activity and Its Mechanisms of Total Coumarins from Artemisia annua

更新时间：2024-01-04

- Preliminary Studies on Antipyretic Activity and Its Mechanisms of Total Coumarins from Artemisia annua
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 12, Pages: 49-51(2008)
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- Published：2008
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GONG Yu-jing1, YAN Han1, LI Ai-yuan2, et al. Preliminary Studies on Antipyretic Activity and Its Mechanisms of Total Coumarins from Artemisia annua[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(12): 49-51.
DOI：

GONG Yu-jing1, YAN Han1, LI Ai-yuan2, et al. Preliminary Studies on Antipyretic Activity and Its Mechanisms of Total Coumarins from Artemisia annua[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(12): 49-51. DOI：

摘要

目的:研究青蒿总香豆素解热(降温)作用并探讨其作用机理。方法:从黄花蒿中提取总香豆素

利用内生致热原性家兔发热模型

观察青蒿总香豆素对发热家兔体温的影响并测定脑脊液、血清中前列腺素E2(PGE2)、环单磷酸腺苷(cAMP)水平以及肝脏、腓肠肌钠泵活性。结果:青蒿总香豆素可以显著降低正常及发热家兔体温

抑制肝脏、腓肠肌组织钠泵活性

降低发热家兔血液及脑脊液PGE2水平

对血液及脑脊液cAMP水平变化无明显影响。结论:香豆素成分可能是青蒿解热降温的有效部位

其作用机制与抑制钠泵活性及降低中枢PGE2水平有关。

Abstract

Objective:To study the antipyretic activity and related mechanisms of total coumarins(TCs) from Artemisia annua.Methods:Total coumarins were extracted from Artemisia annua using Spth method

rectal temperature(Tr) responses were observed in both normothermia and fever rabbits induced by endogenous pyrogens after intraperitoneal treatment of TCs

the concentration of cAMP and PGE2 in either serum or cerebrospinal fluid of fever rabbits was measured by RIA

and Na+

K+-ATPase activity in liver and gastrocnemius was assayed.Results:Administration of TCs reduced Tr in both normothermia and fever rabbits

inhibited the rise of PGE2 in either serum or cerebrospinal fluid from fever rabbits

decreased the Na+

K+-ATPase activity in both liver and gastrocnemius.Conclusion: Coumarins are antipyretic fraction in Artemisia annua

and the inhibition of Na+

K+-ATPase activity and reduction in central PGE2 level may contribute to this activity.

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Related Institution

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