The Effect of Jiaweibiejiajian Pill on Serum IgG of Rats with Hepatic Fibrosis

SUN Hai-yun; REN Ying; YIN Jun-xiang; SONG Chong-shun; YIE Yong-an; YANG Jin-duo; ZHU Zhi-hui; DAI Xin

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The Effect of Jiaweibiejiajian Pill on Serum IgG of Rats with Hepatic Fibrosis

更新时间：2024-01-04

- The Effect of Jiaweibiejiajian Pill on Serum IgG of Rats with Hepatic Fibrosis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 7, Pages: 23-25(2008)
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- Published：2008
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SUN Hai-yun, REN Ying, YIN Jun-xiang, et al. The Effect of Jiaweibiejiajian Pill on Serum IgG of Rats with Hepatic Fibrosis[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(7): 23-25.
DOI：

SUN Hai-yun, REN Ying, YIN Jun-xiang, et al. The Effect of Jiaweibiejiajian Pill on Serum IgG of Rats with Hepatic Fibrosis[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(7): 23-25. DOI：

摘要

目的:观察加味鳖甲煎丸(JWBJ)对肝纤维化大鼠模型血清IgG的影响。方法:用人血清白蛋白和CCl4的方法[1]分别制作大鼠肝纤维化模型

在成模前预防治疗和成模后治疗

用免疫扩散法测定大鼠血清IgG含量。结果:JWBJ预防治疗大

中剂量组及治疗大剂量组与各自的模型组相比均可使白蛋白所致肝纤维化大鼠血清IgG含量明显降低(P<0.05);JWBJ预防治疗大剂量组与模型组相比可使CCl4所致肝纤维化大鼠血清IgG含量明显降低(P<0.05)。结论:JWBJ可降低人血清白蛋白和CCl4所致肝纤维化大鼠过度产生的IgG

表明JWBJ对机体免疫功能有一定的调节作用

对肝纤维化的治疗有一定的参考意义。

Abstract

Objective:To investigate the effects of Jiaweibiejia(JWBJ) Pills on the IgG in serum of hepatic fibrosis rats(HFR).Methods:The rats were randomly divided into control group

model groups

colchine group and Ganpikang group.The model groups were treated or pre-treated with low-dose

middle-dose or high-dose of JWBJ.The serum IgG taken from each group was tested with immunodiffusion method.Results:In the HFR induced by HSA

the level of serum IgG was significantly decreased when treated with the high-dose JWBJ or pre-treated with JWBJ for both middle-dose and high-dose(P<0.05) compared with the matched model group respectively.In the HFR induced by CCl4

only the high-dose of JWBJ pre-treated group significantly decreased the level of serum IgG(P<0.05).Conclusions:JWBJ can decrease the serum IgG in HFR induced by CCl4 or HAS.It sugguest that JWBJ can modulate the immune function and should be considerd in the therapeutic of hepatic fibrosis.

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Related Author

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CUI Jie-feng

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REN Ying

SONG Chong-shun

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SUN Hai-yun

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Related Institution

北京中医药大学东直门医院中药药理学实验室北京100700

Pharmacological Laboratory of Herbal Medicine,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

The First Affiliated Hospital of Dali University，Dali

School of Basic Medical Sciences，Dali University，Dali

Dali Bai Autonomous Prefecture People's Hospital，Dali

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