Objective:To study the effect of active parts in Datura metel L.(APD) for psoriasis on immune function

skin keratinized and epithelial cells mitosis

to clarify the mechanism for clinical applications and developing new drug.Methods:APD's effects on immune function were measured by the content of mice's hemolysin and lymphocyte transformation stimulated by phytohemagglutinin(PHA).The influence on the activity of vaginal epithelial mitotic cells and the effect on skin scales keratosis at the back of tail were also obsevered.Results: APD showed a trend of lowering the content of hemolysin in normal mice;and had no significant impact on lymphocyte transformation stimulated by PHA.APD could significantly inhibit the mitosis of vaginal epithelial cells;and obviously increace the quantities of scaly particles layers of mice tail with a clear role in the promotion of skin keratosis.Conclusion: APD may have no obvious effect on humoral and cell-mediated immunity to the experimental animals.However

APD appears to inhibit with epithelial cell mitosis and promote the keratosis of skin scales obviously.