Background & Objective: Recent studies indicated that nitric oxide synthase(NOS) pathway was involved in angiogenesis around tumor tissues and that tumor necrosis factor-α(TNF-α) and interleukin-2(IL-2) were concerned with the oncogenesis and development of hysteromyoma.In the present study

the effect of Jiliuqing capsules on serum activity of NOS and concentrations of TNF-α and IL-2 in rats with hysteromyoma was investigated to elucidate the possible mechanisms implicated in the anti-tumor effect of Jiliuqing capsules.Methods: Hysteromyoma in rats was established by intramuscular injection of estrogen and progesterone.Following treatment with Jiliuqing capsules for 11 weeks

serum activity of NOS and concentrations of TNF-α and IL-2 were determined.Results: Compared with those in control group

serum activity of NOS and TNF-α concentration in model group were increased significantly

while serum content of IL-2 was decreased markedly.In contrast

treatment with Jiliuqing capsules resulted in an evident decrease in NOS activity and serum level of TNF-α

together with a markedly increased serum concentration of IL-2.Conclusion: Jiliuqing capsules can significantly decrease serum activity of NOS and TNF-α content and increase serum level of IL-2

suggesting that the anti-tumor effect of Jiliuqing capsules on hysteromyoma might be related

at least partly

to the adjustment of endocrine and enhancement of immune function.