Effect of Penetration Enhancers on the Transdermal Penetration of Peoniflorin in the Liaojin Membrares

LI De-tang1; TANG Hong-mei2; QIU Zhen-wen2; ZHANG Li-juan1; SUN Yi-qun2; CHEN Xiao-ye3

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Effect of Penetration Enhancers on the Transdermal Penetration of Peoniflorin in the Liaojin Membrares

更新时间：2024-01-04

- Effect of Penetration Enhancers on the Transdermal Penetration of Peoniflorin in the Liaojin Membrares
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 3, Pages: 62-65(2009)
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- Published：2009
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LI De-tang1, TANG Hong-mei2, QIU Zhen-wen2, et al. Effect of Penetration Enhancers on the Transdermal Penetration of Peoniflorin in the Liaojin Membrares[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(3): 62-65.
DOI：

LI De-tang1, TANG Hong-mei2, QIU Zhen-wen2, et al. Effect of Penetration Enhancers on the Transdermal Penetration of Peoniflorin in the Liaojin Membrares[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(3): 62-65. DOI：

摘要

目的:研究促渗剂对疗筋涂膜剂中芍药苷经皮渗透行为的影响。方法:建立离体经皮渗透试验方法

并作方法学考察。分别在涂膜剂中加入单一及复合促渗剂1%Borneol

3%Borneol

8%Borneol

1%Azone

3%Azone

5%Azone

3%1

2-Propanediol

5%1

2-Propanediol

10%1

2-Propanediol

1%Azone+8%Borneol

3%Azone+8%Borneol

5%Azone+8%Borneol

5%1

2-Propanediol+8%Borneol

5%1

2-Propanediol+8%Borneol+3%Azone和10%1

2-Propanediol+8%Borneol+5%Azone

在相同条件下进行离体经皮渗透试验

测定不同时间的药物累积透过量及增渗倍数。结果:在涂膜剂处方中加入混合促渗剂后

药物累积透过量和增渗倍数明显增加

并高于相应单用促渗剂

5%1

2-Propanediol+8%Borneol+3%Azone促渗剂累积透过量和增渗倍数最高。结论:一定量的促渗剂可使涂膜剂中药物穿透角质层进入真皮层

混合使用促渗剂促透效果明显高于单一使用。

Abstract

Objective:To study the effect of penetration enhancers on the transdermal penetration of peoniflorin in the Liaojin membrares.Methods:We firstly established the experimental method of transdermal penetration

and the methodology study was carried out at the same time.Furthermore

we added 1%Borneol

3%Borneol

8%Borneol

1% Azone

3% Azone and 5% Azone

3% 1

2-Propanediol

5% 1

2-Propanediol

10% 1

2-Propanediol

1% Azone+8%Borneol

3% Azone+8%Borneol

5% Azone+8%Borneol

5% 1

2-Propanediol+8%Borneol

5% 1

2-Propanediol+8%Borneol+3% Azone and 10%1

2-Propanediol+8%Borneol+5% Azone into the membrares.The cumulative penetration amounts and anatonosis multiple were determined during the test of transdermal penetration.Results:The cumulative penetration amounts and anatonosis multiple released from the membrares increased

and the effect to use mix penetration enhancers was far superior compared with penetration enhancers alone.Conclusions:The results indicate that quantitative penetration enhancers can facilitate drug through corneum into dermis

but to use mix penetration enhancers is far superior compared with penetration enhancers alone.

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