Effects of Sesamin on Myocardial Hypertrophy in Renal Hypertensive-hyperlipidemia Rats

KONG Xiang; YANG Jie-ren; GUO Li-qun; ZHOU Yong

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Effects of Sesamin on Myocardial Hypertrophy in Renal Hypertensive-hyperlipidemia Rats

更新时间：2024-01-04

- Effects of Sesamin on Myocardial Hypertrophy in Renal Hypertensive-hyperlipidemia Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 12, Pages: 44-46(2008)
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- Published：2008
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KONG Xiang, YANG Jie-ren, GUO Li-qun, et al. Effects of Sesamin on Myocardial Hypertrophy in Renal Hypertensive-hyperlipidemia Rats[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(12): 44-46.
DOI：

KONG Xiang, YANG Jie-ren, GUO Li-qun, et al. Effects of Sesamin on Myocardial Hypertrophy in Renal Hypertensive-hyperlipidemia Rats[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(12): 44-46. DOI：

摘要

目的:探讨芝麻素对肾性高血压伴高血脂大鼠(RHHR)心肌肥厚的影响。方法:RHHR灌服不同剂量芝麻素(100

10mg·kg-1·d-1)8周后处死动物

计算左室重量指数(LVWI);测定心肌羟脯氨酸(HYD)和硝酸盐/亚硝酸盐(NO-3/NO-2)含量;免疫组化法观察心肌C-fos蛋白表达;透射电镜观察心肌超微结构。结果:100mg.kg-1芝麻素明显降低心肌LVWI

HYD含量和C-fos蛋白表达

升高NO-3/NO-2浓度

改善肌丝排列紊乱

胶原纤维增生等病理变化。结论:芝麻素逆转RHHR心肌肥厚的机制可能与恢复NO水平

降低C-fos蛋白表达有关。

Abstract

Objective:To investigate the improve effect of sesamin on myocardial hypertrophy in renal hypertensive-hyperlipidemia rats(RHHR).Methods: Renal hypertensive-hyperlipidemia rats were orally given with sesamin at dosage of 100

10 mg·kg-1·d-1 respectively.Eight weeks later

rats were sacrificed and the left ventricular weight index(LVWI) was calculated

the contents of hydroxyproline(HYD) and NO-3/NO-2 in myocardium were measured

the expression of Cfos protein was determined by immunohistochemical staining

and the ultramicrostructures of myocardium was observed through electronmicroscope.Results:(100 mg·kg-1·d-1) sesamin decreased LVWI

content of HYD and expression of C-fos protein

increased NO-3/NO-2 concentration

and ameliorated the pathologic changes such as disorder of myofilament and cardiac muscle fibroplasia.Conclusion: The effect of sesamin on attenuating the hypertrophy of myocardium is partialy related with improving NO availability and decreasing expression of C-fos protein.

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Related Author

LI Xian-wei1

YANG Jie-ren1

ZHU Xiao-jun2

LI Xian-wei

XIONG Ke-ren

LI Xian-wei

YANG Jie-ren

XIONG Ke-ren

Related Institution

皖南医学院药理学教研室安徽芜湖241001

Department of Pharmacology,Wannan Medical College

Natural History Museum of China

Beijing Key Laboratory of Chinese Materia Pharmacology，National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases，Institute of Basic Medical Sciences， Xiyuan Hospital，China Academy of Chinese Medical Sciences

School of Clinical Medicine，Beijing University of Chinese Medicine

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