Effect of Combination of Anthraquinone Glucosides from Cassia Seed and Shanzha Total Triterpenoid Acid on Activity of High Density Lipoprotein Receptor in Hyperlipidemic Rabbits
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Effect of Combination of Anthraquinone Glucosides from Cassia Seed and Shanzha Total Triterpenoid Acid on Activity of High Density Lipoprotein Receptor in Hyperlipidemic Rabbits
Chinese Journal of Experimental Traditional Medical FormulaeVol. 15, Issue 1, Pages: 24-28(2009)
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Published:2009
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MA Lu1, JIANG Meng-xi2, LIU Jian-gang3, et al. Effect of Combination of Anthraquinone Glucosides from Cassia Seed and Shanzha Total Triterpenoid Acid on Activity of High Density Lipoprotein Receptor in Hyperlipidemic Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(1): 24-28.
DOI:
MA Lu1, JIANG Meng-xi2, LIU Jian-gang3, et al. Effect of Combination of Anthraquinone Glucosides from Cassia Seed and Shanzha Total Triterpenoid Acid on Activity of High Density Lipoprotein Receptor in Hyperlipidemic Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(1): 24-28.DOI:
Effect of Combination of Anthraquinone Glucosides from Cassia Seed and Shanzha Total Triterpenoid Acid on Activity of High Density Lipoprotein Receptor in Hyperlipidemic Rabbits
目的:观察决明子蒽醌苷与山楂总三萜酸配伍对实验性高血脂症兔血清低密度脂蛋白胆固醇(low density lipoprotein-cholesterol LDL-C)及肝细胞膜高密度脂蛋白受体(high density lipoprotein receptor HDLR)活性的影响。方法:雄性新西兰兔高脂饲养2周形成实验性高血脂症
Objective:To observe the effect of combination of Anthraquinone Glucosides from Cassia Seed(Agc)and Shanzha total triterpenoid acids(Sta) on low density lipoprotein-cholesterol(LDL-C)of serum and activity of high density lipoprotein receptor(HDLR) in hyperlipidemic rabbits.Methords: The best proportion of Agc and Sta was determined by uniform design as the strongest effect on decreasing LDL-C of serum.The best proportional combination of Agc and Sta was given to hyperlipidemic rabbits.Activity of HDLR on the hepatic plasma membranes was measured with 125I.labeled HDL3 as ligand.Results: The results showed that the combination could markedly decrease the level of LDL-C of serum and increase the activity of HDLR at the proportion: Agc∶Sta=1∶2.63.Conclusion: For the best proportion
the combined effect of decreasing in LDL-C was stronger than Agc or Sta or the original prescription.The combination could enhance the activity of HDLR by increasing the number of HDLR.
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