Effect of Naoli Zhibao on Learning and Memory Acquired Disorder Induced by Scopolamine in Mice

JIANG Xue-hua1; LI Rui2; ZHOU Li-ling2

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Effect of Naoli Zhibao on Learning and Memory Acquired Disorder Induced by Scopolamine in Mice

更新时间：2024-01-04

- Effect of Naoli Zhibao on Learning and Memory Acquired Disorder Induced by Scopolamine in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 10, Pages: 42-44(2008)
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- Published：2008
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JIANG Xue-hua1, LI Rui2, ZHOU Li-ling2. Effect of Naoli Zhibao on Learning and Memory Acquired Disorder Induced by Scopolamine in Mice[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(10): 42-44.
DOI：

JIANG Xue-hua1, LI Rui2, ZHOU Li-ling2. Effect of Naoli Zhibao on Learning and Memory Acquired Disorder Induced by Scopolamine in Mice[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(10): 42-44. DOI：

摘要

目的:探讨脑力智宝对东莨菪碱所致学习记忆获得障碍小鼠的保护作用与机制。方法:腹腔注射东莨菪碱制备学习记忆获得障碍模型小鼠

以跳台法观察脑力智宝对模型小鼠学习记忆能力的影响

并检测血清与脑内胆碱酯酶活性、脑内游离氨基酸的含量。结果:脑力智宝能显著改善模型小鼠的学习记忆能力

有效抑制血清及脑内胆碱酯酶的活性

并显著提高脑内谷氨酸(Glu)、天门冬氨酸(Asp)水平

降低γ-氨基丁酸(GABA)水平。结论:脑力智宝增强小鼠的学习记忆获得过程的作用机制可能与抑制胆碱酯酶合成、提高脑内Glu/GABA比值有关。

Abstract

Objective:To study the effect of Naoli Zhibao(NLZB) on learning and memory acquired disorder induced by Scopolamine.Methods:Scopolamine was injected intraperitoneally to induce learning and memory acquired disorder in mice.The learning and memory capability of mice was investigated by step-down test

the activity of acetylcholinesterase(AChE) in serum and brain and the contents of free amino acids were measured.Results:NLZB significantly promoted the learning and memory capability of mice

and depressed the activity of AChE in serum and brain.On the other hand

NLZB could increase the contents of glutamate acid(Glu) and aspartic acid(Asp) in brain while the content of gamma-aminobutyric acid(GABA) was decreased.Conclusion:It is suggested that NLZB not only could regulate the center cholinergic system by depressing the activities of AchE and improving the level of acetylcholine in brain

but also could increase Glu/GABA ratio

which might be one of the mechanislms of NLZB to reinforcing intelligence.

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Related Institution

School of Basic Medical Sciences， Hubei University of Chinese Medicine

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Engineering Research Center of Traditional Chinese Medicine Protection Technology and New Product Development for the Elderly Brain Health， Ministry of Education， Hubei University of Chinese Medicine

School of Traditional Chinese Medicine， Hubei University of Chinese Medicine

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