Effects of Biyan Spray on Expression of Adhesion Molecule in Nasal Mucosa in Allergic Rhinitis Rat
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Effects of Biyan Spray on Expression of Adhesion Molecule in Nasal Mucosa in Allergic Rhinitis Rat
Chinese Journal of Experimental Traditional Medical FormulaeVol. 14, Issue 7, Pages: 67-69(2008)
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Published:2008
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YUAN Ying, FU Sheng-guang, Guo Xin. Effects of Biyan Spray on Expression of Adhesion Molecule in Nasal Mucosa in Allergic Rhinitis Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(7): 67-69.
DOI:
YUAN Ying, FU Sheng-guang, Guo Xin. Effects of Biyan Spray on Expression of Adhesion Molecule in Nasal Mucosa in Allergic Rhinitis Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(7): 67-69.DOI:
Effects of Biyan Spray on Expression of Adhesion Molecule in Nasal Mucosa in Allergic Rhinitis Rat
Objective:To observe the effect of the Biyan spray on expression of ICAM-1
VCAM-1 in nasal mucosa in allergic rhinitis(AR) rat and to explore the mechanism of Biyan spray treating AR.Methods: Using the model of AR rats caused by OVA
we observed the effect of Biyan spray on expression of ICAM-1
VCAM-1 in nasal mucosa by immunohistochemical staining method.Results: The expressions of ICAM-1
VCAM-1 in nasal mucosa were significantly higher than those in the control group.Biyan spray can depress the expression of ICAM-1 and VCAM1.Conclusions: One of mechanisms of Biyan spray treating AR may restrain adhesion molecules in nasal mucosa to restrict the aggregation and migration of inflammation cells.
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Related Institution
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine
Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences
Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences
China Association of Chinese Medicine
Institute of Otolaryngology & Head and Neck Surgery, Dongzhimen Hospital, Beijing University of Chinese Medicine