Proteinuria and Transforming Growth Factor β1 in Rat Model of Glomerulosclerosis and the Intervention by Compound of Huoxue Bushen
|更新时间:2024-01-04
|
Proteinuria and Transforming Growth Factor β1 in Rat Model of Glomerulosclerosis and the Intervention by Compound of Huoxue Bushen
Chinese Journal of Experimental Traditional Medical FormulaeVol. 14, Issue 10, Pages: 34-36(2008)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2008
稿件说明:
移动端阅览
DUAN Xiao-hong1, DONG Jing-cheng1, HE Li-qun2, et al. Proteinuria and Transforming Growth Factor β1 in Rat Model of Glomerulosclerosis and the Intervention by Compound of Huoxue Bushen[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(10): 34-36.
DOI:
DUAN Xiao-hong1, DONG Jing-cheng1, HE Li-qun2, et al. Proteinuria and Transforming Growth Factor β1 in Rat Model of Glomerulosclerosis and the Intervention by Compound of Huoxue Bushen[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(10): 34-36.DOI:
Proteinuria and Transforming Growth Factor β1 in Rat Model of Glomerulosclerosis and the Intervention by Compound of Huoxue Bushen
Objective:To investigate in proteinuria and transforming growth factor β1(TGF-β1) in rat model of glomerulosclerosis and the intervention of Huoxue Bushen compound.Method:The rats model of glomerulosclerosis was developed by useing of unilateral nephrectomy plus doxorubicin injection.The experimental animals were randomly divided into normal control group
model group
western medicine control group
Chinese medicine prevention group and Chinese medicine treatment group.Dynamic observation of protein in urine during 24 h
and detection of plasma and kidney tissue of TGF-β1.Results:Proteinuria in glomerular sclerosis in rats showed a certain degree of change.With the progress of glomerulosclerosis
serum TGF-β1 increased tendenciously.Huoxue Bushen compound can reduce initial 24 h protein in urine of glomerulosclerosis.Conclusion:Compared with the normal control group
urine protein in the rat model group continued to increase.TGF-β increased in serum and kidney tissue.Huoxue Bushen compound can reduce glomerulosclerosis in the early proteinuria.
Research on Qingxianfang's Function on Anti-hepatic Fibrosis in Rats
Investigation of Qinzao Jiufei Recipe and Astragalus membranaceus on Radioprotection of Lung and Expression of Plasma Transfroming Growth Factor Beta-1 and Interleukin-1
Transforming Growth Factor- Stimulates the Proliferation of Rat Lung Fibroblasts
Effects of Buyang Huanwu Decoction on Expression of TGF-/Smad3 in Pulmonary Fibrosis Rats
Investigation of Qinzao Jiufei Recipe and Astragalus membranaceus on Radioprotection of Lung and Expression of Plasma Transfroming Growth Factor Beta-1 and Interleukin-1
Related Author
DONG Shang-pu5
ZHANG Lin-jun1
LIU Guang-hui1
HUANG Dong-hua1
CHANG Geng2
YANG Yun-fang3
ZHANG Yan-hong1
RONG Jing1
Related Institution
Jiangyin Hospital of Medical College.Southeast University,Jiangyin