Effect of Danggui Buxue Decoction on Promoting Function Reconstruction of Hematopoietic Tissue after Bone Marrow Transplantation
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Effect of Danggui Buxue Decoction on Promoting Function Reconstruction of Hematopoietic Tissue after Bone Marrow Transplantation
Chinese Journal of Experimental Traditional Medical FormulaeVol. 14, Issue 10, Pages: 39-41(2008)
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Published:2008
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XU Rui-rong, CUI Xing, WANG Yan, et al. Effect of Danggui Buxue Decoction on Promoting Function Reconstruction of Hematopoietic Tissue after Bone Marrow Transplantation[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(10): 39-41.
DOI:
XU Rui-rong, CUI Xing, WANG Yan, et al. Effect of Danggui Buxue Decoction on Promoting Function Reconstruction of Hematopoietic Tissue after Bone Marrow Transplantation[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(10): 39-41.DOI:
Effect of Danggui Buxue Decoction on Promoting Function Reconstruction of Hematopoietic Tissue after Bone Marrow Transplantation
Objective:To investigate the effect of Danggui Buxue Decoction on function reconstruction of hematopoietic tissue in mice after bone marrow isotransplanttation(iso-BMT).Methods:The typical mouse model of iso-BMT was established.The model mice were randomly divided into BMT+Danggui Buxue Decoction treatment group(treated with Danggui Buxue Decoction by gastrogavage) and BMT model group(treated with normal saline by gastrogavage).PB and BM of normal mice were obtained as blank.The following parameters were observed in the day 1
11 and 22:peripheral blood cells
bone marrow mono-nuclear cells(BMMNC)
and the observation of bone marrow under microscope.Results:The levels of peripheral WBC
RBC
platelet
BMMNC
and the observation of bone marrow by microscope at the day 11 and 22 in BMT+Danggui Buxue Decoction treatment group were all significantly better than that of BMT model group(P<0.05 or P<0.01).Conclusion:Danggui Buxue Decoction could improve the function reconstruction of hematopoietic tissue.
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China Academy of Traditional Chinese Medicine (TCM) Medical Experimental Center, Beijing Key Laboratory of Basic Research on Prevention and Treatment of Major Diseases by TCM
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