Study on Pharmacokinetics of Syringopicroside in Rabbits
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Study on Pharmacokinetics of Syringopicroside in Rabbits
Chinese Journal of Experimental Traditional Medical FormulaeVol. 14, Issue 9, Pages: 44-46(2008)
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Published:2008
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LI Qiu-hong, LI Yong-ji, SUI Xiao-fan, et al. Study on Pharmacokinetics of Syringopicroside in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(9): 44-46.
DOI:
LI Qiu-hong, LI Yong-ji, SUI Xiao-fan, et al. Study on Pharmacokinetics of Syringopicroside in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(9): 44-46.DOI:
Study on Pharmacokinetics of Syringopicroside in Rabbits
Objective:To identify pharmacokinetics of syringopicroside in rabbits.Methods:The plasma samples were collected after intravenous injection and syringopicroside was determined by HPLC after solid-phase extraction.The data were analyzed with software Multi97 and the pharmacokinetic parameters were calculated.Results:Two compartment model was shown after syringopicroside administration.The main pharmacokinetic parameters are presented respectively: T1/2(α)=2.655 min
T1/2(β)=16.54 min
AUC=272.32 μg·mL-1·min
CL=(0.037 1 mL·min-1)
K12=(0.090 8 min-1)
K21=0.124 min-1.Conclusion:The pharmacokinetics of syringopicroside showed a rapid distribution
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