Objective:To set up the quality standard of Cortex Moutan dispensing granules.Methods: TLC experiments were performed on a plates of silica gel using two solvent systems by gradient development.The contents of paeonol and paeoniflorin in the dispensing granules were determined simultaneously by HPLC.Concentrations of heavy metals(Cu

Pb

Cd

As and Hg) in the samples were analyzed by AAS and AFS.Results: paeonol and paeoniflorin in the dispensing granules were identified and determined.The linear relationship were at the ranges of(24～120) μg·mL-1(r=(0.999 6)) for paeonol and(10.6～53.0) μg·mL-1(r=(0.999 8)) for paeoniflorin.The average recoveries were 98.1% for paeonol and 97.6% for paeoniflorin respectively.The quantity of 5 elements analyzed were below the limits.Conclusion: The methods were available with a good reproducibility and can be used to control the quality of Cortex Moutan.dispensing granules.