Determination of Active Components in Fufang Yemazhui Capsule

SHEN Hong1; QIAN Da-wei1; ZHU Ling-ying1; ZHANG Xiao-ling2; DUAN Jin-ao3

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Determination of Active Components in Fufang Yemazhui Capsule

更新时间：2024-01-04

- Determination of Active Components in Fufang Yemazhui Capsule
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 5, Pages: 12-13(2008)
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- Published：2008
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SHEN Hong1, QIAN Da-wei1, ZHU Ling-ying1, et al. Determination of Active Components in Fufang Yemazhui Capsule[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(5): 12-13.
DOI：

SHEN Hong1, QIAN Da-wei1, ZHU Ling-ying1, et al. Determination of Active Components in Fufang Yemazhui Capsule[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(5): 12-13. DOI：

摘要

目的:建立新药复方野马追胶囊中活性物质的测定方法。方法:运用反相高效液相色谱法测定复方野马追胶囊中绿原酸、黄芩苷的含量

流动相分别为:乙腈∶0.1mol·L-1磷酸二氢钠缓冲液(磷酸调pH3.4)(5∶95);甲醇∶0.4%磷酸(49∶51)

分离度良好。结果:绿原酸在(0.092～1.38)μg进样量范围内

R值为0.9999;重复性:RSD=1.14%;平均加样回收率:99.06%

RSD=1.93%。黄芩苷在(0.084～2.52)μg进样量范围内

r=0.9999;重复性:RSD=0.63%;平均加样回收率:99.22%

RSD=0.97%。结论:所建立的含量测定方法准确、简便

可有效控制复方野马追胶囊的质量。

Abstract

Objective:To develop an HPLC method to determin active components in Fufang Yemazhui Capsule.Methods: The mobile phase for chlorogenic acid determination consisted of acetonitrile and 0.1 mol·L-1 sodium dihydrogen phosphate buffer(pH 3.4 adjusted by Phosphoric acid)(5∶95).The mobile phase for baicalin determination consisted of methanol and 0.4%phosphoric acid(49∶51).The resolution is good enough.Results: A good linear relationship of chlorogenic acid was showed between(0.092～1.38) μg and the repeatability was fine(RSD=1.14%).The average recovery was 99.06%

(RSD=1.93%).The linear relationship of baicalin was also good between(0.084～2.52) μg.The repeatability was fine(RSD=0.63%).The average recovery was 99.22%

(RSD=0.97%).Conclusion: This method was accurate and simple.The Quality of Fufang Yemazhui Capsule cloud be controlled effectively.

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Related Institution

College Pharmacy of Xinjiang Medical University

China Academy of Chinese Medical Sciences Orthopedics Institute

Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory， Jiangxi Province Key Laboratory of TCM Etiopathogenisis， Jiangxi University of Chinese Medicine

The Second Clinical Medical College， Henan University of Chinese Medicine

Henan Academy of Chinese Medicine

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