Follow-up Study on Treatment of Mild Cognitive Impairment by Modified Wuzi Yanzong Granule

FU Hong; WANG Xue-mei; LIU Geng-xin; YANG Jin-xia; LI Li; ZHU Wei

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Follow-up Study on Treatment of Mild Cognitive Impairment by Modified Wuzi Yanzong Granule

更新时间：2024-01-04

- Follow-up Study on Treatment of Mild Cognitive Impairment by Modified Wuzi Yanzong Granule
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 2, Pages: 67-70(2008)
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- Published：2008
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FU Hong, WANG Xue-mei, LIU Geng-xin, et al. Follow-up Study on Treatment of Mild Cognitive Impairment by Modified Wuzi Yanzong Granule[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(2): 67-70.
DOI：

FU Hong, WANG Xue-mei, LIU Geng-xin, et al. Follow-up Study on Treatment of Mild Cognitive Impairment by Modified Wuzi Yanzong Granule[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(2): 67-70. DOI：

摘要

目的:观察轻度认知障碍(mild cognitive impairment

MCI)患者服用加味五子衍宗颗粒3个月及停药1年的疗效及转归。方法:参照目前国际公认的MCI诊断标准

筛选出36例MCI患者

采用随机双盲分组

分为加味五子衍宗颗粒治疗组(简称治疗组18例)和安慰剂对照组(简称对照组18例)

服药3个月

观察用药前后记忆功能及药物安全性

随访1年。另选20名健康人为正常对照组(简称正常组)。结果:MCI患者的记忆商(MQ)较健康人明显降低(P<0.01)。用药后

治疗组的MQ较其用药前明显提高(P<0.01)

且较对照组治疗前后MQ的差值有明显提高(P<0.05)。随访1年

服药组无1例发生不良反应

停药1年治疗组的MQ仍较其用药前有明显提高(P<0.01)。对照组有2例MCI患者转化为痴呆。结论:加味五子衍宗颗粒能改善MCI患者的记忆功能

且有防治MCI向痴呆发展的作用。

Abstract

Objective:To observe the effect of mild cognitive impairment(MCI)on Treatment by Modified Wuzi Yanzong Granule(MWYG) for 3 months and after drug withdrawal 1 year.Methods: According to the international accepted diagnostic criteria

36 MCI patients were selected and randomly assigned two groups equally

the treated group treated with MWYG(18 cases) and the control group with placebo(18 cases)

with a course of 3 months for both groups and followed up for 1 year. Besides

20 healthy subjects were selected as the normal group.The changes of memory ability and safety before and after treating were observed.Results: Memory quotient(MQ) was significantly lower in MCI patients than in healthy subjects(P<0.01).After treatment it increased in the treated group as compared with that before treatment(P<0.01)

and the inerement was higher the that in the control group(P<0.05).After drug withdrawal 1 year

there was still increase in MQ(P<0.01) than that before treatment in MWYG group

no adverse reaction was found in two groups

and there were two cases of the control group developed into dementia in the elderly.Conclusion: MWYG could improve MCI patients' memory ability and could prevent from MCI into dementia in the elderly.

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