Studies on Anti-HBV Effect in vitro of Snail Polysaccharide

ZHAN Xiao-dong1; WANG Ke-xia2; LI Chao-pin1

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Studies on Anti-HBV Effect in vitro of Snail Polysaccharide

更新时间：2024-01-04

- Studies on Anti-HBV Effect in vitro of Snail Polysaccharide
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 3, Pages: 66-68(2008)
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- Published：2008
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ZHAN Xiao-dong1, WANG Ke-xia2, LI Chao-pin1. Studies on Anti-HBV Effect in vitro of Snail Polysaccharide[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(3): 66-68.
DOI：

ZHAN Xiao-dong1, WANG Ke-xia2, LI Chao-pin1. Studies on Anti-HBV Effect in vitro of Snail Polysaccharide[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(3): 66-68. DOI：

摘要

目的:探讨蜗牛多糖抗乙肝病毒活性。方法:将不同浓度蜗牛多糖与HepG2.2.15细胞株共培养

以拉米夫定为阳性对照药

用ELISA法检测HBsAg和HBeAg分泌水平

实时荧光定量PCR检测HBVDNA含量

计算抑制率。结果:蜗牛多糖在体外能有效抑制HepG2.2.15细胞HBsAg和HBeAg分泌

最大抑制率分别为42.8%和52.1%;对HBVDNA的复制有一定抑制作用(P<0.05)。结论:蜗牛多糖在体外具有显著的抗乙型肝炎病毒作用

且毒性较小

具有良好应用前景。

Abstract

Objective:To evaluate the anti-HBV effect of snail polysaccharide(SP).Methods:HepG2.2.15 cell strain was used in vitro

and we applied Lamivudine as positive control.ELISA was adopted to detect the level of HBsAg and HBeAg in supernatant.The quantity of HBV DNA was checked by RT-PCR.The inhibition ratio was calculated of SP on HBV.Results:SP had a inhibiting effect on the HBsAg and HBeAg with maximum inhibition ratio adding up to 42.8% and 52.1% respectively.There was certain inhibition on replication of HBV DNA(P<0.05).Conclusions:SP has a noticeable anti-HBV effect in vitro with low toxicity

which shows a fine applying prospect.

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