Study on Antitumor Action of Xiaoliu Tang in Mice

ZHAO Hong-bo; LIU Jian-guo

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Study on Antitumor Action of Xiaoliu Tang in Mice

更新时间：2024-01-04

- Study on Antitumor Action of Xiaoliu Tang in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 12, Pages: 51-52(2007)
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- Published：2007
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ZHAO Hong-bo, LIU Jian-guo. Study on Antitumor Action of Xiaoliu Tang in Mice[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(12): 51-52.
DOI：

ZHAO Hong-bo, LIU Jian-guo. Study on Antitumor Action of Xiaoliu Tang in Mice[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(12): 51-52. DOI：

摘要

目的:探讨中药复方消瘤汤对小鼠肝癌模型的抗肿瘤作用。方法:用腋下注射Hep G2细胞造成小鼠腋下皮下肿瘤移植模型

给予小鼠消瘤汤灌胃后查看对肿瘤组织的抑制作用;采用四甲基偶氮唑盐(MTT)法检测消瘤汤含药血清对HepG2细胞的生长抑制作用;用PCR ELISA法测定HepG2细胞端粒酶的活性。结果:药物组瘤重明显比生理盐水组小

以大剂量组最为明显

抑制率达41.88%;MTT法显示肿瘤细胞抑制率与药物剂量呈直线关系;消瘤汤大剂量组对肝癌组织端粒酶活性有明显的抑制作用(P<0.01)。结论:消瘤汤有明显的抗实验性小鼠肝癌的作用

有可能与抑制肿瘤细胞端粒酶活性有关。

Abstract

Objective:To investigate the effect of anti-implanted tumour of Xiaoliu Tang in mice.Methods:To make a mode of implanted tumor with injecting HepG2 cells in the axilla of mice.The inhibitory effect on tumor was observed for the mice after Xiaoliu Tang was given orally.The inhibitory effect in HepG2 by Xiaoliu Tang with the method of MTT was investigated.Telomerase activity of HepG2 cells was observed with the method of PCR

ELISA.Results:The tumor in the administration groups was smaller than that of the controls

especially for in the big-dosage group(the inhibitatory rate is 41.88%).The results of MTT showed that the inhibitory rate of HepG2 cells was in dose dependent fashion.The high-dosage treatment group have significant inhibitory effect on telomerase activity of hepatocarcinoma.Conclusions:Xiaoliu Tang can inhibit hepatocarcinoma;its mechanism may correlate to inhibiting telomerase activity.

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Related Institution

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