Study on the Depressant Effect of Compound Qingre Granule-Serum on Extended-Spectrum Beta-Lactamase
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Study on the Depressant Effect of Compound Qingre Granule-Serum on Extended-Spectrum Beta-Lactamase
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 11, Pages: 40-43(2007)
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Published:2007
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YANG Jun1, ZHANG Shu-wen2, YIN Cheng-hong2, et al. Study on the Depressant Effect of Compound Qingre Granule-Serum on Extended-Spectrum Beta-Lactamase[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(11): 40-43.
DOI:
YANG Jun1, ZHANG Shu-wen2, YIN Cheng-hong2, et al. Study on the Depressant Effect of Compound Qingre Granule-Serum on Extended-Spectrum Beta-Lactamase[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(11): 40-43.DOI:
Study on the Depressant Effect of Compound Qingre Granule-Serum on Extended-Spectrum Beta-Lactamase
Objective:To observe the depressant effect of the Compound Qingre Granule-Serum(SQ)on extended-spectrum beta-lactamase(ESBLs).Methods:According to ultraviolet spectrophotometry
different concentration SQ's β-lactamase inhibiting effect was determined.The effect was tested by changes of optical density in ultraviolet light induced by ampicillin.Results:33.3% SQ can inhibit the β-lactamase effect of ATCC700603 more than 50%
and had significant difference to control group.The β-lactamase inhibiting effect of SQ also showed positive correlation with its concentration.Conclusion:SQ can inhibit the action of ESBLs significantly.It may be one of the mechanisms of the granule for curing drug-resistance bacteria infections.
Shuguang Hospital, Institute of Liver Diseases, Key Laboratory of Liver and Kidney Disease (Ministry of Education), Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shanghai University of Traditional Chinese Medicine (TCM)
Institute of Chinese Materia Medica, Institute of Interdisciplinary Integrative Medicine, Shanghai University of TCM
Key Laboratory of Modern Preparation of TCM Ministry of Education, Jiangxi University of TCM