Protecting Effect of Huanglianjiedutang on Multiple Organ Dysfunction Syndrome in Rats

REN Jian-hua1; 2; CHENG Ning1; LIN Zheng-jia2; CHEN Zhong-teng3; WENG Shu-he2

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Protecting Effect of Huanglianjiedutang on Multiple Organ Dysfunction Syndrome in Rats

更新时间：2024-01-04

- Protecting Effect of Huanglianjiedutang on Multiple Organ Dysfunction Syndrome in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 4, Pages: 63-65(2008)
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- Published：2008
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REN Jian-hua1, 2, CHENG Ning1, et al. Protecting Effect of Huanglianjiedutang on Multiple Organ Dysfunction Syndrome in Rats[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(4): 63-65.
DOI：

REN Jian-hua1, 2, CHENG Ning1, et al. Protecting Effect of Huanglianjiedutang on Multiple Organ Dysfunction Syndrome in Rats[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(4): 63-65. DOI：

摘要

目的:探讨黄连解毒汤对多器官功能障碍综合征(MODS)大鼠脏器的保护作用。方法:采用腹腔注射酵母多糖的方法复制大鼠MODS模型

观察黄连解毒汤(HLJDT)对MODS大鼠血浆丙氨酸转氨酶(ALT)、肌酐(Cr)、呼吸(R)、心率(HR)及组织病理的影响。结果:造模后各时段

治疗组动物血浆丙氨酸转氨酶、肌酐、呼吸、心率比模型组显著降低

且小肠、肝、肾和肺脏等组织病理也明显改善。结论:黄连解毒汤对MODS大鼠脏器具有一定的保护作用。

Abstract

Objective:To evaluate the protective effect of Huanglianjiedutang(HLJDT) on multiple organ dysfunction syndrome(MODS) in rats.Methods:Animal model was induced by intraperitoneal administration of zymosan.Sixty SD rats were randomly divided into control group

model group

HLJDT low-dosage and high-dosage groups.The content of aminotransferase and creatinine in plasma was examined

respiration rate and heart rate of every group were examined and the pathological change of the main organs in every period were examined.Results:Results showed that the content of aminotransferase and creatinine in plasma

respiration rate and heart rate of treatment Groups were significantly decrease compared with model group.The histopathological change of small intestine

liver

kidney and lung of treatment groups was significantly improved compared with model group.Conclusions:HLJDT has protective effects on MODS in rats.

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