Effect of Bushen Jieyu Qinxin Decoction on the Behavior and Secretion of Hypothalamus-Pituitary-Adrenal Axis of the Perimenopausal Depression Model in Rat

DONG Li; JIANG Lin; MENG Wei; ZHU Nan-sun

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Effect of Bushen Jieyu Qinxin Decoction on the Behavior and Secretion of Hypothalamus-Pituitary-Adrenal Axis of the Perimenopausal Depression Model in Rat

更新时间：2024-01-04

- Effect of Bushen Jieyu Qinxin Decoction on the Behavior and Secretion of Hypothalamus-Pituitary-Adrenal Axis of the Perimenopausal Depression Model in Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 5, Pages: 63-65(2008)
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- Published：2008
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DONG Li, JIANG Lin, MENG Wei, et al. Effect of Bushen Jieyu Qinxin Decoction on the Behavior and Secretion of Hypothalamus-Pituitary-Adrenal Axis of the Perimenopausal Depression Model in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(5): 63-65.
DOI：

DONG Li, JIANG Lin, MENG Wei, et al. Effect of Bushen Jieyu Qinxin Decoction on the Behavior and Secretion of Hypothalamus-Pituitary-Adrenal Axis of the Perimenopausal Depression Model in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(5): 63-65. DOI：

摘要

目的:探讨补肾解郁清心方对围绝经期抑郁症模型大鼠行为学的影响和对下丘脑-垂体-肾上腺轴(HPA轴)的调节作用。方法:采用雌性SD大鼠双侧卵巢摘除

孤养与慢性轻度不可预见应激二步法制作围绝经期抑郁症动物模型。将40只大鼠分为正常对照组、模型组、西药组、中药组。西药组予百忧解(2.4mg·kg-1)与苯甲酸雌二醇(0.1mg·kg-1)

中药组予补肾解郁清心方(40g·kg-1

相当于临床成人剂量的10倍)。对大鼠进行Open-field行为学评分

糖水消耗实验

用酶联免疫吸附测定法(ELISA)检测血清促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)、皮质酮(CORT)含量。结果:西药组和中药组Open-field水平积分、垂直积分及糖水消耗量均高于模型组(P<0.01);西药组和中药组血清CRH

CORT含量均低于模型组(P<0.05)

ACTH含量有下降趋势。结论:补肾解郁清心方能够改善围绝经期抑郁症模型大鼠行为

调节HPA轴功能。

Abstract

Objective:To study the effect of Bushen Jieyu Qinxin Decoction(BJQD) on the behavior and secretion of the hypothalamus-pituitary-adrenal(HPA) axis of the perimenopausal depression model in rat.Methods:Perimenopausal depression modle was made by resecting the ovary of female SD rats combined with chronic unpredictable stress.40 rats were evenly randomized into control group

perimenopausal depression model group

Baiyoujie group and BJQD group

with 10 rats in each group.Open-field locomotors scores and sucrose intake were employed to observe the changes of the rats' behavior.The levels of corticotrophin releasing hormone(CRH)

adrenocorticotropic hormone(ACTH) and costicosterone(CORT) in serum were determined by enzyme linked immunosorbent assay.Results:The open-field locomotors scores of Baiyoujie group and BJQD group were significantly higher than those in the model group(P<0.01);the sucrose intake of Baiyoujie group and BJQD group were significantly higher than those in the model group(P<0.01);the levels of CRH

ACTH and CORT in serum of Baiyoujie group and BJQD group were significantly lower than those of in the model group(P<0.05).Conclusion:BJQD can effectively promote the model rats' behavior and adjust the function of HPA axis.

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