Effect of the Qing xin KaiqiaoFang on Contents of Free Radicals Metabolism in Brain and Morphology of Hippocampal Nerve Cells in AD Mice
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Effect of the Qing xin KaiqiaoFang on Contents of Free Radicals Metabolism in Brain and Morphology of Hippocampal Nerve Cells in AD Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 10, Pages: 57-60(2007)
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Published:2007
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ZHU Wei-ming1, HU Hai-yan2. Effect of the Qing xin KaiqiaoFang on Contents of Free Radicals Metabolism in Brain and Morphology of Hippocampal Nerve Cells in AD Mice[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 57-60.
DOI:
ZHU Wei-ming1, HU Hai-yan2. Effect of the Qing xin KaiqiaoFang on Contents of Free Radicals Metabolism in Brain and Morphology of Hippocampal Nerve Cells in AD Mice[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 57-60.DOI:
Effect of the Qing xin KaiqiaoFang on Contents of Free Radicals Metabolism in Brain and Morphology of Hippocampal Nerve Cells in AD Mice
Objective:To study the effects of the Qing Xin KaiqiaoFang(QXKQF) on contents of free radicals metabolism in brain and shape hippocampal nerve cells in Alzheimer disease(AD) mice.Methods:One handred fifty mice were divid into five groups:blank group
model group
two groups of treatment by QXKQF(14.82 g·kg-1)
7.41 g·kg-1)
Piracetan comparison group(0.42 g·kg-1).The model group was orally given AlCl3(200 mg·kg-1)every day.For QXKQF and Piracetan groups
AlCl3 treatment was given 6 days at the begining
followed by giving orally AlCl3 in the morning and drug in the afternoon for 8 weeks.Then
learning and memory ability
free radicals metabolism in brain(SOD、MDA、LF) and morphology of hippocampal nerve cells were investigated.Results:QXKQF can prevent hippocampal nerve cells from damage obviously.The SOD increased
the contents of MAD and LF were lowered compared with model group(P<0.01).Learning and memory ability of QXKQF groups is improved
compared with model group(P<0.05~0.01).Conclusion:QXKQF can improve learning and memory ability of AD mice
protect hippocampal nerve cells
resist oxidation and reduce free radicals injure for AD mice.
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