Experimental Study on Effect of Xinguanxinsuhe Drop Pill on ISO-Induced Acute Myocardium Ischemia
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Experimental Study on Effect of Xinguanxinsuhe Drop Pill on ISO-Induced Acute Myocardium Ischemia
Chinese Journal of Experimental Traditional Medical FormulaeVol. 14, Issue 3, Pages: 56-58(2008)
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Published:2008
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LI Guo-chuan, LI Chun-xiang, DING Li-yu, et al. Experimental Study on Effect of Xinguanxinsuhe Drop Pill on ISO-Induced Acute Myocardium Ischemia[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(3): 56-58.
DOI:
LI Guo-chuan, LI Chun-xiang, DING Li-yu, et al. Experimental Study on Effect of Xinguanxinsuhe Drop Pill on ISO-Induced Acute Myocardium Ischemia[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(3): 56-58.DOI:
Experimental Study on Effect of Xinguanxinsuhe Drop Pill on ISO-Induced Acute Myocardium Ischemia
Objective:To observe the effect of Xinguanxinsuhe Drop Pill(XDP)Ⅰ、Ⅱ and Guanxinsuhe capsule on isoprenaline(ISO)-induced acute myocardium ischemia.Methods:Acute myocardium ischemia rat model was established by i.p of ISO.The level of NO
malondialdehyde(MDA)and superoxide dismutase(SOD)in myocardial homogenate and the content of AST in serum were observed after ISO injection.Rat ECG was also recorded.Results:XDP Ⅰ and Ⅱ could significantly increase NO
SOD activity and decrease content of MDA
AST and improve the abnormity of ECG(P<0.05
P<0.01).Conclusion:The result showed that compare with XDPⅡ and Guanxinsuhe capsule
XDP Ⅰ could prevent myocardial ischemia injure more effectively.