Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami

Yang Qing; LIANG Ri-xin; YE Jin-xia; WANG Lan; YANG Bin; FU Mei-hong; HUANG Lu-qi

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Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami

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- Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 11, Pages: 30-33(2007)
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- Published：2007
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Yang Qing, LIANG Ri-xin, YE Jin-xia, et al. Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(11): 30-33.
DOI：

Yang Qing, LIANG Ri-xin, YE Jin-xia, et al. Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(11): 30-33. DOI：

摘要

目的:采用大鼠高脂血症模型观察红花提取物降血脂作用

并进行安全性评价。方法:采用高脂饲料喂养大鼠造成高脂血症模型

口服给药1个月后

腹主动脉采血

测定血清甘油三酯(TG)

总胆固醇(TC)

低密度脂蛋白胆固醇(LDL-C)

高密度脂蛋白胆固醇(HDL-C);小鼠急性毒性实验和大鼠30d喂养实验。结果:红花水提物明显降低高脂血症大鼠TC

LDL-C;对小鼠最大耐受量大于106.7g生药/kg。大鼠30d喂养实验

动物无一死亡

无明显中毒症状

各项观察指标不随剂量的增大和受试时间的延长出现剂量反应关系。结论:红花提取物对高脂血症大鼠具有辅助降血脂功能

且无明显的毒性作用。

Abstract

Objective:To observe the function of decreasing blood-lipid by extract from Flos carthami in rat with hyperlipidemia and safety of water extract.Methods:Using hyperlipidemia animal model replicated by hyperlipidemia forage

the levels of TC

HDL

LDL were assayed;actue toxicity test and thirty days feeding study were employed.Results:The levels of TG

LDL-C in all groups treated with the water extract of Flos Carthami were significantly reduced.The alcohol extract of Flos carthami showed a decreased action for TC.For safety

water extract showed no death nor toxic symptom.All the observed index showed no relationship between postponing time and increasing doses during 30 d feeding period.And in teratogenicity tests

pregnant rats grew well;fetuses developed naturally

and the ratio of abnormal fetues was in the range of natural abnormal ratio.Conclusions:The extract of Flos carthami indicaterd the function of decreasing the blood-lipid

and no obvious toxic effects have been observed.

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Related Author

HUANG Lu-qi

FU Mei-hong

YANG Bin

WANG Lan

YANG Qing

LIANG Ri-xin

YE Jin-xia

CHENG Long

Related Institution

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

中国中医科学院中药研究所北京100700

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