Phamacodynamic Studies of Yiganfuzheng Capsule

JIN Cui-ying1; ZHOU Jian-ping1; MA Bao-shan1; LI Zhuang2; CHEN Hong-shan2

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Phamacodynamic Studies of Yiganfuzheng Capsule

更新时间：2024-01-04

- Phamacodynamic Studies of Yiganfuzheng Capsule
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 10, Pages: 41-44(2007)
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- Published：2007
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JIN Cui-ying1, ZHOU Jian-ping1, MA Bao-shan1, et al. Phamacodynamic Studies of Yiganfuzheng Capsule[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 41-44.
DOI：

JIN Cui-ying1, ZHOU Jian-ping1, MA Bao-shan1, et al. Phamacodynamic Studies of Yiganfuzheng Capsule[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 41-44. DOI：

摘要

目的:研究乙肝扶正胶囊的主要药效学作用。方法:选用D-半乳糖胺致小鼠急性肝损伤模型、卡介苗+脂多糖(BCG+LPS)造成小鼠免疫性肝损伤模型、四氯化碳(CCl4)致大鼠慢性肝损伤模型

研究乙肝扶正胶囊的保肝作用。选用鸭乙型肝炎病毒感染雏鸭

以分子斑点杂交法观察其对鸭血清乙型肝炎病毒DNA水平的影响。观察对环磷酰胺抑制免疫功能小鼠血清溶血素含量的影响。结果:乙肝扶正胶囊能明显降低D-半乳糖胺致急性肝损伤和BCG+LPS致免疫性肝损伤模型小鼠血清中ALT、AST的含量;对CCl4慢性肝损伤大鼠模型可降低血清中ALT、AST及肝羟脯氨酸含量

提高TP、ALB含量。对肝损伤均有明显的修复作用。对乙型肝炎病毒感染鸭血清DHBV-DNA水平抑制效果显著

拮抗环磷酰胺所致的体液免疫抑制

增加小鼠血清溶血素含量。结论:乙肝扶正胶囊有一定的保肝降酶、抑制鸭乙型肝炎病毒复制、提高机体免疫力的作用。

Abstract

Objective:To investigate pharmacological effects of Yiganfuzheng Capsule on liver.Method:The acute liver injury model

the immunological liver injury model

the chronic liver injury model were caused by D-galactosamine

BCG+LPS and carbon tetrachloride

respectively.The ducklings were infected by hepatitis B virus.The dot-hybridization test was used to evaluate the duck hepatitis B virus's DNA level in serum.The haemolysin test was used to investigate the effect on the immunosuppressive model caused by the cycophosphamide.Result:The Yiganfuzheng Capsule can markedly decrease the content of the ALT and AST in the serum of the acute liver injury model caused by D-galactosamine and by BCG+LPS.Levels of ALT

AST in serum and hydroxyproline in liver were decreased

and the TP

ALB were increased

compared with the model group(P<0.01

P<0.05).It had inhibitory effect on the level of DHBV-DNA in the serum of duckling infected by hepatitis B.It could antagonize the humoral immunity inhibition caused by cyclophophamide

increased the level of serum haemolysin in mouse.Conclusion:Yiganfuzheng Capsule has effects of protecting liver

decreasing enzyme

inhibiting copy of duck hepatitis B virus

and enhancing the body immune function.

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Related Institution

School of Life Science,Beijing Institute of Technology

北京理工亘元医药技术开发中心有限公司

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