Protective Effect of Liuwei Dihuang Wan and its Constituents Absorbed into Blood After Oral Administration on Hydrocortisone Inducing Renal Deficiency in Rat
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Protective Effect of Liuwei Dihuang Wan and its Constituents Absorbed into Blood After Oral Administration on Hydrocortisone Inducing Renal Deficiency in Rat
Chinese Journal of Experimental Traditional Medical FormulaeVol. 14, Issue 2, Pages: 33-37(2008)
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Published:2008
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WANG Xi-jun1, ZHANG Ning1, SUN Hui1, et al. Protective Effect of Liuwei Dihuang Wan and its Constituents Absorbed into Blood After Oral Administration on Hydrocortisone Inducing Renal Deficiency in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(2): 33-37.
DOI:
WANG Xi-jun1, ZHANG Ning1, SUN Hui1, et al. Protective Effect of Liuwei Dihuang Wan and its Constituents Absorbed into Blood After Oral Administration on Hydrocortisone Inducing Renal Deficiency in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(2): 33-37.DOI:
Protective Effect of Liuwei Dihuang Wan and its Constituents Absorbed into Blood After Oral Administration on Hydrocortisone Inducing Renal Deficiency in Rat
Objective:To elucidate bioactive constituents for invigorating the kidney in Liuwei Dihuang Wan based on study on protective effect of Liuwei Dihuang Wan and its constituents absorbed into blood after oral administration on hydrocortisone inducing renal deficiency in rat.Method: Seventy rats were randomly divided into seven groups including control
model
total components
5-HMFA
mixture containing morroniside
sweroside and loganin
paeonol and LW group.For continous 9 days
every group rat was respectively orally administrated with distilled water
distilled water
total components
5-HMFA mixture containing morroniside
sweroside and loganin
paeonol and LW
from 5 day to 9 day
control group rat was subcutaneously injected with sodium chloride at a dose of 5 ml/kg body weight
the other groups rat was subcutaneously injected with hydrocortisone at a dose of 25 mg/kg body weight(5 ml/kg).On 10th day
collected samples for analyzing 10 batches of indexes.Result: Every group drugs all improved such 10 batches of indexs in a large
the effect of mixture containing morroniside
sweroside and loganin group is most significantly.Conclusion: It is found that determined constituents absorbed into blood after oral administration of Liuwei Dihuang Wan is mainly bioactive constituents for invigorating the kidney
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Related Institution
School of Basic Medicine, Gansu University of Chinese Medicine
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