The Effect of Xuefuzhuyu Granule on Acute Myocardial Ischemia in Anesthetized Dogs
|更新时间:2024-01-04
|
The Effect of Xuefuzhuyu Granule on Acute Myocardial Ischemia in Anesthetized Dogs
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 10, Pages: 35-36(2007)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2007
稿件说明:
移动端阅览
LU Hang1, WANG Qiu-jing2, LIU Fen2, et al. The Effect of Xuefuzhuyu Granule on Acute Myocardial Ischemia in Anesthetized Dogs[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 35-36.
DOI:
LU Hang1, WANG Qiu-jing2, LIU Fen2, et al. The Effect of Xuefuzhuyu Granule on Acute Myocardial Ischemia in Anesthetized Dogs[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 35-36.DOI:
The Effect of Xuefuzhuyu Granule on Acute Myocardial Ischemia in Anesthetized Dogs
Objective:To observe the influence of Xuefuzhuyu Granule(XFZHYG) on coronary circulation and serum enzymes of acute myocardial ischemia in anesthetized dogs.Methods:Twenty-four dogs were devided at random into four groups:(1) model group(2)XFZHYG 5.0 g·kg-1 group(3)XFZHYG 2.5 g·kg-1 group(4)XFZHYG 5.0 g·kg-1 group.The parameters of the coronary circulation and the changes of the enzymes in serum were determined by using the acute myocardial ischemia model of left anterior descending branch(LAD) in the anaesthetized dogs.Results:The coronary resistance(P<0.05) was decreased
the myocardial blood flow was increased(P<0.05) in dogs treated with XFZHYG of 2.5
5.0 g·kg-1.The activities of serum LA
FFA and MDA were decreased(P<0.01
P<0.05)
the SOD and GSH-Px were increased(P<0.05) in acute myocardial ischemia dogs treated with of XFZHYG 2.5
5.0 g·kg-1.Conclusion:XFZHYG has protective effect on myocardial ischemia through the changes in serum enzymes
decreasing coronary vascular resistance and increasing the myocardial blood flow in dogs.