Effect of Danxiongfang on Reducing Serum Lipids Level in Rat Model with Hyperlipidemia Induced by High-lipid Diet
|更新时间:2024-01-04
|
Effect of Danxiongfang on Reducing Serum Lipids Level in Rat Model with Hyperlipidemia Induced by High-lipid Diet
Chinese Journal of Experimental Traditional Medical FormulaeVol. 14, Issue 3, Pages: 42-45(2008)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2008
稿件说明:
移动端阅览
LI Xiao-rong1, WANG Li-juan1, LI Yu-hang1, et al. Effect of Danxiongfang on Reducing Serum Lipids Level in Rat Model with Hyperlipidemia Induced by High-lipid Diet[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(3): 42-45.
DOI:
LI Xiao-rong1, WANG Li-juan1, LI Yu-hang1, et al. Effect of Danxiongfang on Reducing Serum Lipids Level in Rat Model with Hyperlipidemia Induced by High-lipid Diet[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(3): 42-45.DOI:
Effect of Danxiongfang on Reducing Serum Lipids Level in Rat Model with Hyperlipidemia Induced by High-lipid Diet
Objective:To explore the effect of danxiongfang on reducing serum lipid in experimental hyperlipidemic rat model induced by high-fat diet.Methods: The rats were fed with high-fat diet for 4 weeks to establish the hyperlipidemic model
then lovastatin
cholestyramine
danxiongfang high
medium
and low doses were given to the rats orally for 4 weeks.The serum TG
TC
HDL-C
LDL-C
ALT
ALb were detected at the end of 4 weeks.The pathological changes of liver
heart
stomach tissues stained with HE were observed under light microscope.Results: The rats developed hyperlipidemia with high serum lipid levels
serum ALT and ALb concentration also increased significantly.Each drug showed significant inhibition for the increases in serum lipid
ALT
and serum ALb.Histopathological examination of liver
heart and stomach showed that pathologic injuries were ameliorated by each drugs.Conclusion: Danxiongfang showed powerful lipid regulating and liver protective effect.
Clinical Efficacy of Zhuyuwan in Treatment of Hyperlipidemia with Syndrome of Phlegm Turbidity and Obstruction
Zhuyuwan in Treatment of Hyperlipidemia Complicated with Carotid Atherosclerosis: A Randomized Controlled Trial
Mechanism of Wendantang in Intervention of ApoE-/- Hyperlipidemic Mice Based on Liver Metabolomics
Polygonati Odorati Rhizoma Polysaccharides Ameliorate Hyperlipidemia in Mice by Regulating Gut Microbiota
Wendantang Regulates Energy Metabolism in Treatment of Myocardial Ischemia via SIRT3/PGC-1α Pathway
Related Author
YANG Lele
LUO Danmei
CHEN Jiao
ZHANG Xiaobo
SONG Wei
ZHU Wenyu
ZHOU Xin
LI Xueping
Related Institution
Chengdu University of TCM
Hospital of Chengdu University of Traditional Chinese Medicine (TCM)
Hospital of Chengdu University of TCM
Chengdu University of Traditional Chinese Medicine(TCM)
Research Center for Differentiation and Development of Traditional Chinese Medicine (TCM) Basic Theory/Jiangxi Province Key Laboratory of Biological Etiologies of TCM/First-Level Discipline Platform of Chinese and Western Integrative Medicine/Experimental Animal and Scientific Technology Center of Jiangxi University of Chinese Medicine/School of Pharmacy, Jiangxi University of Chinese Medicine