Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease
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Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 9, Pages: 37-40(2007)
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Published:2007
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SUN Jie, ZHAO Hong-liang, WANG Jun-xia, et al. Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(9): 37-40.
DOI:
SUN Jie, ZHAO Hong-liang, WANG Jun-xia, et al. Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(9): 37-40.DOI:
Effects of Feixintong Capsules on the Levels of IL-8 and TNF-α in Rat Model of Chronic Pulmonary Heart Disease
Objective:To research the effect and the mechanism of Feixintong on rat model of chronic pulmonary heart disease(CPHD).Methods:50 Wistar rats were randomly divided into five groups.Rats were given a single injection of monocrotaline(MCT
60 μg/g)to induce the model of CPHD.The Feixintong groups were treated by suspension in 21 days
then total white cell counts and differential counts and interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)were examined.Lung organism slices were observed with microscope.Results:The examined items of the Feixintong groups were lower than the model groups(P<0.01 or P<0.05)
endotheliocytes were repaired by Feixintong.Conclusions:Feixintong has good efficacy for treatment of rat model of CPHD.