Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease

SUN Jie; WNAG Jun-xia; ZHAO Hong-liang; WU Li-wen

您当前的位置：

首页 >

文章列表页 >

Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease

更新时间：2024-09-23

- Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 8, Pages: 36-38(2007)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2007
- 稿件说明：
移动端阅览
SUN Jie, WNAG Jun-xia, ZHAO Hong-liang, et al. Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(8): 36-38.
DOI：

SUN Jie, WNAG Jun-xia, ZHAO Hong-liang, et al. Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(8): 36-38. DOI：

摘要

目的:探讨肺心通对慢性肺源性心脏病(CPHD)大鼠的治疗效果及其作用机理。方法:50只Wistar大鼠

雌雄各半

随机分为空白组、模型组、肺心通高、中、低剂量组

以2%野百合碱(MCT)按60mg/kg1次腹腔注射复制CPHD大鼠模型。同时给模型组、肺心通高、中、低剂量组灌胃相应药物

连续用药21d。测定大鼠血清和肺组织匀浆中一氧化氮(NO)、内皮素-1(ET-1)的含量;测定肺小动脉及支气管平滑肌血管内皮细胞生长因子(VEGF)的表达;观察肺组织病理形态学改变。结果:肺心通可显著提高CPHD模型大鼠的NO含量;降低ET-1的含量;降低大鼠肺小动脉及支气管平滑肌中VEGF的表达;改善肺组织的病理改变。结论:肺心通对CPHD大鼠有较好的治疗作用。

Abstract

Objective:To research the functionary mechanism and treating effect of Feixintong(FXT) on chronic pulmonary heart disease(CPHD).Methods:50 Wister rats were randomly separated into five groups:blank control group

model group

FXT groups of high

middle and low dosage

The rat model of corpulmonale was established by injecting 2% monocrotaline(60 mg/kg)i.p.At the same time

model group

FXT groups of high

middle and low dosage were separately administrated with physical saline or FXT for 21 days.NO

ET-1 and expression of VEGF in bronchi arterioles was measured.Lung tissue sections were examined to study the morphological alternations.Results:FXT could evidently improve the NO content of rat model of CPHD;reduce the ET-1 content;reduce the expression of VEGF in bronchi arterioles.Conclusions:FXT treatment is effective on rat model of CPHD.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease

Related Author

SUN Jie~

WNAG Jun-xia

ZHAO Hong-liang

WU Li-wen

Related Institution

Gansu College of TCM

甘肃中医学院甘肃兰州730000

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰