Pharmacokinetics and Salivary Distribution of Chlorogenic acid for Shuanghuanglian Injection at High-dose

LI Qiu-hong; FENG Yu-fei; LIU Pei-li; CUI Ming-yu

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Pharmacokinetics and Salivary Distribution of Chlorogenic acid for Shuanghuanglian Injection at High-dose

更新时间：2024-01-04

- Pharmacokinetics and Salivary Distribution of Chlorogenic acid for Shuanghuanglian Injection at High-dose
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 5, Pages: 47-49(2008)
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- Published：2008
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LI Qiu-hong, FENG Yu-fei, LIU Pei-li, et al. Pharmacokinetics and Salivary Distribution of Chlorogenic acid for Shuanghuanglian Injection at High-dose[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(5): 47-49.
DOI：

LI Qiu-hong, FENG Yu-fei, LIU Pei-li, et al. Pharmacokinetics and Salivary Distribution of Chlorogenic acid for Shuanghuanglian Injection at High-dose[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(5): 47-49. DOI：

摘要

目的:明确双黄连粉针剂高剂量给药时有效成分绿原酸在大鼠体内的动态变化规律及其在唾液中的分布情况。方法:大鼠740mg·kg-1静脉注射双黄连粉针后

反相高效液相色谱法测定绿原酸在血液、唾液中的浓度

采用Multi97进行统计处理

确定药动学参数。结果:绿原酸在大鼠体内符合二室模型分布

其主要药动学参数如下:t1/2=0.63h

AUC=62.40μg·h-1·mL-1

Vc=3.58L

CL=4.03L·h-1。绿原酸的唾液浓度范围为:(0.42～9.88)μg·mL-1。结论:双黄连粉针高剂量给药时绿原酸呈非线性药动学消除过程

在唾液中的分布浓度较低。

Abstract

Objective:To identify pharmacokinetics and salivary distribution of Chlorogenic acid after high-dose administration of Shuanghuanglian Injection in rats.Methods:Each rat was given a 740 mg·kg-1 dose of Shuanghuanglian Injection via the vein.RP-HPLC method was used to determine the concentrations of Chlorogenic acid in plasma and saliva.Pharmacokinetic model and parameters were analyzed by program Multi97.Results:Chlorogenic acid showed two compartment model in rats and the main parameters of pharmacokinetics were as follows: t1/2=0.63 h

AUC=62.40 μg·h·mL-1

Vc=3.58 L

CL=4.03 L·h-1.The salivary level of Chlorogenic acid was within(0.42～9.88) μg·mL-1.Conclusion:These results suggested that Chlorogenic acid would present nonlinear pharmacokinetics

and Chlorogenic acid was excreted lowly into saliva.

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