Experimental Study on Antiviral Effect of Protoporphyrin Disodium on Duck Hepatitis B Virus

LIU Qun-hong; FAN Qiao-yun

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Experimental Study on Antiviral Effect of Protoporphyrin Disodium on Duck Hepatitis B Virus

更新时间：2024-01-04

- Experimental Study on Antiviral Effect of Protoporphyrin Disodium on Duck Hepatitis B Virus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 14, Issue 3, Pages: 46-47(2008)
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- Published：2008
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LIU Qun-hong, FAN Qiao-yun. Experimental Study on Antiviral Effect of Protoporphyrin Disodium on Duck Hepatitis B Virus[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(3): 46-47.
DOI：

LIU Qun-hong, FAN Qiao-yun. Experimental Study on Antiviral Effect of Protoporphyrin Disodium on Duck Hepatitis B Virus[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(3): 46-47. DOI：

摘要

目的:研究原卟啉二钠(PPN)抗鸭乙型肝炎病毒(DHBV)的作用。方法:采用先天感染DHBV的龙岩麻鸭为动物模型

分设模型对照组、拉米呋啶组和PPN组

各组按20mg·kg-1·d-1灌胃给药10d

斑点杂交法观察用药前、用药5d、10d及停药后3d血清中DHBVDNA表达

HE染色观察肝脏组织病理学变化。结果:PPN组于用药后5d1、0d

血清DHBVDNA水平分别为1.36±0.261、.05±0.28

与模型对照组2.04±0.05、1.90±0.31比较明显降低(T5P<0.05、T10P<0.01)

病理检查发现PPN组肝细胞点状坏死明显减轻

与模型对照组比较

差异有显著性(P<0.05)。结论:PPN有抑制DHBVDNA的作用

并具有明显的抗炎、保肝作用。

Abstract

Objective:To study the anti-duck Hepatitis B virus(DHBV) action of protoporphyrin disodium(PPN).Methods: Longyan ducks with congenital infection of HBV were used as the animal model and the each group of ducks was given the drug with the doses 20 mg·kg-1·d-1 for 10 successive days.DHBV-DNA in serum was detected by dot-hybridization test before treatment

5 days and 10 days after treatment

the pathological changes of the duck liver were also examined by HE staining.Results: After giving medication with PPN for 5 days and for 10 days

the optic density value of DHBV-DNA in ducks serum were obviously lower than that before treated(1.36±0.26

1.05±0.28 VS 2.04±0.05

1.90±0.31)

there were remarkable difference(P<0.01

P<0.05).Spotty hepatocyte necroses in treatment group was improved more obviously than that in model group.Conclusion: PPN can protect duck liver against inflammation by the inhibition of DHBV.

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