Studies on Antipyretic Mechanism of Chaijing Injection-interfere with Content of AVP and PGE in Rat Hypothalamus
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Studies on Antipyretic Mechanism of Chaijing Injection-interfere with Content of AVP and PGE in Rat Hypothalamus
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 12, Pages: 31-33(2007)
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Published:2007
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WANG Su-jun, CHEN Zhao, ZHENG Jun, et al. Studies on Antipyretic Mechanism of Chaijing Injection-interfere with Content of AVP and PGE in Rat Hypothalamus[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(12): 31-33.
DOI:
WANG Su-jun, CHEN Zhao, ZHENG Jun, et al. Studies on Antipyretic Mechanism of Chaijing Injection-interfere with Content of AVP and PGE in Rat Hypothalamus[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(12): 31-33.DOI:
Studies on Antipyretic Mechanism of Chaijing Injection-interfere with Content of AVP and PGE in Rat Hypothalamus
Objective:To study the effect of Chaijing injection on in febrile rats induced by zymonsa and content of AVP as well as PGE2 in rat hypothalamus.Provide a scientific evidence for the antipyretic mechanism.Methods:Rats febrific model were made by 20% high-activity zymonsa
the effective mechanism of Chaijing Injection was probed in antipyretic action on temperature and cut off rat hypothalamus
the radioimmunoassay(RIA) was established for the determination of AVP and PGE2 in hypothalamus.Results:①The rat was injected by way of subcutaneous with 20% zymonsa that could cause rat febrific model.The Chaijing Injection had a obviously antipyretic effect on febrile rats
the effect in 3 mL·kg-1 group was remarkably better than that in 2 mL·kg-1 group.②The content of AVP and PGE2 in hypothalamus of rats in treated group with Chaijing Injection had a significant lowering compared with the model control group.Conclusions:The content of AVP and PGE2 in hypothalamus of rats could be reduced by treated group with Chaijing Injection.Both AVP and PGE2 were important endogenic mediums that were secreted in hypothalamus
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