Effect of (San Qi) and (Jiao Gu Lan) on Vascular Remodeling in Rabbits

WEN Xiao-Ping1; ZHENG Xiao-jie1; Hiroya Kawasaki2; Takehito Tanbo2; Masahiko Nonaka2; CHEN De-xing1

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Effect of (San Qi) and (Jiao Gu Lan) on Vascular Remodeling in Rabbits

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- Effect of (San Qi) and (Jiao Gu Lan) on Vascular Remodeling in Rabbits
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 8, Pages: 24-28(2007)
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- Published：2007
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WEN Xiao-Ping1, ZHENG Xiao-jie1, Hiroya Kawasaki2, et al. Effect of (San Qi) and (Jiao Gu Lan) on Vascular Remodeling in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(8): 24-28.
DOI：

WEN Xiao-Ping1, ZHENG Xiao-jie1, Hiroya Kawasaki2, et al. Effect of (San Qi) and (Jiao Gu Lan) on Vascular Remodeling in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(8): 24-28. DOI：

摘要

目的:研究三七、绞股蓝单方及配伍方对实验性兔动脉粥样硬化(AS)模型血管重构的影响。方法:64只3～4月龄新西兰雄兔随机分为正常组(Control)、模型组(Model)、三七组(SQ)、绞股蓝组(JGL)、复方组(FF)、卡托普利组(Captopril)。除正常对照组外

均予耳缘静脉注射牛血清白蛋白250mg/kg后继喂高脂饲料

同时各药物组给予相应的药物

连续12周。于12周末行胸主动脉HE、EF(弹力纤维)染色

观测VSMC(血管平滑肌细胞)核个数、EF的变化;免疫组织化学标记胸主动脉PCNA(增殖细胞核心抗原)、TGF-β1(转化生长因子-β1)表达。结果:(1)与模型组比较

各药物组主动脉病变不同程度减轻

尤以复方组为优;(2)复方组与模型组比较VSMC核个数显著下降;(3)模型组与正常组比较

主动脉PCNA数密度百分数、TGF-β1面积百分比显著升高(P<0.01)

各药物组有不同程度的降低。结论:三七、绞股蓝及复方通过降低TGF-β1表达

减轻该因子致细胞增殖的作用

减轻血管壁肥厚性重构。

Abstract

Objective:To investigate the effects and mechanisms of Panax notoginseng(SQ) and Gynostemma pentaphyllum(JGL) on vascular remodeling.Methods:A total of sixity-four male New Zealand rabbits was randomly divided into six groups:Normal

Model

JGL

FF(SQ+JGL) and Captopril.The rabbits in control group were fed with regular diet

others were injected with bovine serum albumin 250 mg/kg and fed with high cholesterol diet

meanwhile

durgs were administrated orally.Rabbits were sacrificed at the end of 12 week

aortas serial crosssections were stained with hematoxylin-eosin and elastic fibers.Immunohistochemistry were performed to label PCNA and TGF-β1.Results:(1)The pathological changes of all drug treated groups were alleviated.(2)Compound prescription decreased the quantity of aorta VSMC nucleus compared with model group(P<0.05).(3)The aorta PCNA immunostaining number and TGF-β1 immunostaining area of model group were significantly higher than normal group(P<0.01)

all drug treated groups decreased.Conclusion:Reduced expression of TGFβ1

and cellular proliferation may be related with inhibition of VR.

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Related Author

WEN Xiao-Ping~1

ZHENG Xiao-jie~1

Hiroya Kawasaki~2

Takehito Tanbo~2

Masahiko Nonaka~2

CHEN De-xing~

YU Juan

CHEN De-xing

Related Institution

日本味之素株式会社

Chengdu University of Traditional Chinese Medicine（TCM）

Hospital of Chengdu University of TCM

Hubei Minzu University

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