Pharmacokinetic Studies of Naringenin and Hesperetin in Human Plasma after Oral Administration of Zhizhu Wan
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Pharmacokinetic Studies of Naringenin and Hesperetin in Human Plasma after Oral Administration of Zhizhu Wan
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 8, Pages: 18-20(2007)
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Published:2007
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WANG Xi-jun1, CHEN Xi1, CAO Hong-xin2, et al. Pharmacokinetic Studies of Naringenin and Hesperetin in Human Plasma after Oral Administration of Zhizhu Wan[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(8): 18-20.
DOI:
WANG Xi-jun1, CHEN Xi1, CAO Hong-xin2, et al. Pharmacokinetic Studies of Naringenin and Hesperetin in Human Plasma after Oral Administration of Zhizhu Wan[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(8): 18-20.DOI:
Pharmacokinetic Studies of Naringenin and Hesperetin in Human Plasma after Oral Administration of Zhizhu Wan
Objective:Elucidating the pharmacokinetic properties of Zhizhu Wan.Method:By using β-Glucuronidase
free hesperintin and naringenin were obtained from the hesperetin-glucronide naringenin-glucronaide in plasma
the contents of the two compounds in plasma was determined by HPLC.Results:T1/2(ka)/T1/2(ke)(h) for naringenin and hesperetin are 2.142±0.999/5.491±3.926 and 2.106±0.728/5.824±3.067 respectively
and the AUC(mg/L·h) value are 34.886±22.199 and 39.407±19.535 for naringenin and hesperetin respectively.Conclusion:The method for determinning naringenin and hesperetin in plasma has been established
and the pharmacokinetic parameters can be instructive for clinic apllication.