Optimized Preparation of Drug in Adhesive Transdermal Patch by Central Composite Design/Response Surface Methodology

YU Yang; ZHOU Li-ling; WEI Min; LI Xiu-mei

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Optimized Preparation of Drug in Adhesive Transdermal Patch by Central Composite Design/Response Surface Methodology

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- Optimized Preparation of Drug in Adhesive Transdermal Patch by Central Composite Design/Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 9, Pages: 14-16(2007)
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- Published：2007
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YU Yang, ZHOU Li-ling, WEI Min, et al. Optimized Preparation of Drug in Adhesive Transdermal Patch by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(9): 14-16.
DOI：

YU Yang, ZHOU Li-ling, WEI Min, et al. Optimized Preparation of Drug in Adhesive Transdermal Patch by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(9): 14-16. DOI：

摘要

目的:优化粘胶分散型透皮贴剂的处方。方法:以大鼠皮肤为实验屏障

初粘力与体外透皮速率常数为评价指标

采用星点设计-效应面法优化贴剂处方中增塑剂、交联剂和促渗剂的最佳配比。结果:各指标的二项式拟合方程均优于多元线性回归方程

优化处方中增塑剂:交联剂:促渗剂所占比例分别为45%

2.8%

7.4%。结论:建立的模型可较好地描述该实验中因素与指标的关系

预测性良好。

Abstract

Objective:To optimize the preparation of drug in adhesive transdermal patch.Methods:Taking SD mouse skin as protective screen of the experiment and tackness and transdermal speed constant of vitro as evaluation index to optimize the best matching of plasticizer

cross-linking agent and penetration enhancer in transdermal patch.Results:Second-order quadratic models of index are superior to the plural linear regress equation

plasticizer:cross-linking agent:penetration enhancer is 45%∶2.8%∶7.4%.Conclusions:In this experiment

the established model can describe the relation between factor and index and the outcome of prediction is good.

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Related Author

YU Yang

ZHOU Li-ling~

WEI Min

LI Xiu-mei

HUANG Yuan-hong

WEI Tian-xi

ZHANG Fa-sheng

YANG Jun-xuan

Related Institution

Guangzhou of TCM

广州中医药大学广东广州510405

College of Pharmacy,Shenyang Pharmaceutical University

College of Pharmacy,Chengdu University of Traditional Chinese Medicine

成都中医药大学中药资源系统研究与开发利用省部共建国家重点实验室培育基地

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