Influence of Shenfu Injection on the Serum level of Endogenous Digoxin-Like Substance In Rats with Heart Failure
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Influence of Shenfu Injection on the Serum level of Endogenous Digoxin-Like Substance In Rats with Heart Failure
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 7, Pages: 29-30(2007)
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Published:2007
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MAO Jing-yuan1, WEI Guang-li2, WANG Heng-he1, et al. Influence of Shenfu Injection on the Serum level of Endogenous Digoxin-Like Substance In Rats with Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(7): 29-30.
DOI:
MAO Jing-yuan1, WEI Guang-li2, WANG Heng-he1, et al. Influence of Shenfu Injection on the Serum level of Endogenous Digoxin-Like Substance In Rats with Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(7): 29-30.DOI:
Influence of Shenfu Injection on the Serum level of Endogenous Digoxin-Like Substance In Rats with Heart Failure
Objective:To evaluate the influence of Shenfu Injection(SFI) on the serum level of endogenous digoxin-like substance(EDLS) in rats with heart failure(HF).Methods:HF models were built up by ligating the left coronary artery of rats.Twenty-four model rats with HF were randomly divided into 4 groups:the control one(normal saline 12 ml/kg iv) and the low
middle and high dosage ones of SFI(normal saline plus SFI of 4 ml
8 ml
12 ml/kg iv respectively)
6 rats in each one.The serum levels of EDLS in the rats were examined by radioimmunoassay(RIA)before and after the medication.Results:Different dosage of SFI all showed the tendency of increasing the serum level of EDLS of the rats with HF.After the medication
the serum level of EDLS was risen at once
and maintained for 8 hours at least
the peak value appeared twice at 0.5 h and 4 h.Conclusion: SFI could increase the secretion and release of EDLS in the rats with HF.
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