Experimental Study of Gongning Granule on Uterus Haemorrhage Induced by Drug-abortion

LIANG Ai-hua; XUE Bao-yun; WANG Jin-hua; LI Chun-ying

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Experimental Study of Gongning Granule on Uterus Haemorrhage Induced by Drug-abortion

更新时间：2024-01-04

- Experimental Study of Gongning Granule on Uterus Haemorrhage Induced by Drug-abortion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 2, Pages: 55-57(2007)
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- Published：2007
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LIANG Ai-hua, XUE Bao-yun, WANG Jin-hua, et al. Experimental Study of Gongning Granule on Uterus Haemorrhage Induced by Drug-abortion[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 55-57.
DOI：

LIANG Ai-hua, XUE Bao-yun, WANG Jin-hua, et al. Experimental Study of Gongning Granule on Uterus Haemorrhage Induced by Drug-abortion[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 55-57. DOI：

摘要

目的:研究宫宁颗粒对大、小鼠药物流产后子宫出血的治疗作用。方法:孕7d大鼠或小鼠一次性灌胃给予米非司酮8mg/kg(大鼠)

12mg/kg(小鼠)

诱发孕鼠流产子宫出血模型。于流产当日

灌胃给予宫宁颗粒3

12g生药/kg

每日给药1次

连续5d。测定大、小鼠子宫出血量:小鼠出、凝血时间;大鼠凝血酶原时间(PT)、凝血酶时间(TT)、部分凝血活酶时间(APTT)。结果:宫宁颗粒6

12g生药/kg可减少大、小鼠流产后的子宫出血量;缩短大鼠PT

显示有明显的止血作用。结论:宫宁颗粒对药物流产后的子宫出血有明显的止血作用。

Abstract

Objective:To investigate the effect of Gongning Granule on uterus haemorrhage induced by drug-abortion in mice and rats.Methods:Pregnant mice or rats were intragastrically(ig) administrated with mifepristone 8 mg/kg in rats or 12 mg/kg in mice at day 7 postgestational to induce uterus haemorrhage.The mice or rats were treated with Gongning Granule ig at doses of 3

12 g crude drug/kg body weight

once a day for consecutive 5 days.The amount of uterus haemorrhage of mice and rats

bleeding time and clot time of mice

TT and APTT of rats were tested.Results: Gongning Granule of 6

12 g/kg decreased the amount of uterus haemorrhage of mice and rats

shortened the PT and TT of rats.The results indicated that Gongning Granule has an obvious hemostasia effect.Conclusion: Gongning Granule have an obvious hemostasia effect on uterus haemorrhage induced by drug-abortion.

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