Study X on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO  Supercritical Fluid Extract (P) on Astrocyte Anoxic Injury

Liu Jie; LIN Zhi-hong; ZHU Dan-ni; YAN Yong-qing; YU Bo-yang

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Study X on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO Supercritical Fluid Extract (P) on Astrocyte Anoxic Injury

更新时间：2024-09-23

- Study X on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO Supercritical Fluid Extract (P) on Astrocyte Anoxic Injury
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 8, Pages: 14-17(2007)
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- Published：2007
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Liu Jie, LIN Zhi-hong, ZHU Dan-ni, et al. Study X on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO Supercritical Fluid Extract (P) on Astrocyte Anoxic Injury[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(8): 14-17.
DOI：

Liu Jie, LIN Zhi-hong, ZHU Dan-ni, et al. Study X on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO Supercritical Fluid Extract (P) on Astrocyte Anoxic Injury[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(8): 14-17. DOI：

摘要

目的:观察当归芍药散精简方(FBD)及其CO2超临界萃取物(P2)对体外培养的大鼠乳鼠皮质星形胶质细胞缺氧损伤的保护作用。方法:SD大鼠po FBD 125mg/kg或P216.3mg/kg后

采集含药脑脊液(CSF-FBD/P2);MTT法测定FBD、P2人工脑脊液(ACSF-FBD/P2)及其含药脑脊液(CSF-FBD/P2)对Na2S2O4诱导星形胶质细胞缺氧损伤的保护作用。结果:1mmol/LNa2S2O4作用1h复氧4h可显著降低星形胶质细胞活力(P<0.01);(0.1～1)mg/LACSF-FBD和5%～15%CSF-FBD可显著促进缺氧损伤星形胶质细胞活力(P<0.01);(0.01～1)mg/L ACSF-P2和15%CSF-P2可极显著或显著促进缺氧损伤星形胶质细胞活力(P<0.01～0.05)。结论:FBD及其CO2超临界萃取物对星形胶质细胞缺氧损伤具有保护作用。

Abstract

Objective:To observe the protective effect of FBD

the simplified formula from Danggui Shaoyao San(DSS)

and CO2 supercritical fluid extract(P2) on the hypoxic astrocyte anoxic injury.Methods:Sampling cerebrospinal fluid containing FBD/P2(CSF-FBD/P2) after administration with FBD 125 mg/kg or P2 16.3 mg/kg;MTT assay was used to measure the viability in the damaged astrocyte induced by Na2S2O4.Results:1 h hypoxia and 4 h reoxygen significantly decreased the viability in astrocyte(P<0.01);(0.1～1)mg/L ACSF-FBD and 5%～15% CSF-FBD can substantially increase the viability of astrocyte induced by Na2S2O4(P<0.01);(0.01～1) mg/L ACSF-P2 and 15% CSF-P2 can substantially increase the viability of astrocyte(P<0.01～0.05).Conclusion:FBD and P2 could prevent astrocyte from Na2S2O4-induced hypoxic damage

which was beneficial to the treatment of cerebral ischemia.

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Related Author

LIU Jie

LIN Zhi-hong

ZHU Dan-ni

YAN Yong-qing

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XIE Jiarun

LIN Haoyu

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Related Institution

Department of Chinese Medicinal Prescription,China Pharmaceutical University

中国药科大学中药复方研究室江苏南京210038

Zhujiang Hospital of Southern Medical University

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MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials

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