Study of the Regulating Effect and the Mechanism of Wendan Decoction on Disorder of Lipid Metabolism in Rat
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Study of the Regulating Effect and the Mechanism of Wendan Decoction on Disorder of Lipid Metabolism in Rat
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 7, Pages: 44-46(2007)
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Published:2007
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WU Xiao-yu, WANG Yan, MA Bo-yan, et al. Study of the Regulating Effect and the Mechanism of Wendan Decoction on Disorder of Lipid Metabolism in Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(7): 44-46.
DOI:
WU Xiao-yu, WANG Yan, MA Bo-yan, et al. Study of the Regulating Effect and the Mechanism of Wendan Decoction on Disorder of Lipid Metabolism in Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(7): 44-46.DOI:
Study of the Regulating Effect and the Mechanism of Wendan Decoction on Disorder of Lipid Metabolism in Rat
Objective:To study the regulating effect and the mechanism of Wendan decoction on disorder of lipid metabolism in rat.Methods:The model rats of disorder of lipid metabolism have been established by feeding high-fat emulsion Ocally.The regulating effects of Wendan decoction on triglyceride(TG)
total cholesterol(TG)
super oxide dismutase(SOD)
malondialdehyde(MDA)
lipoprotein lipase(LPL)
hepatic lipase(HL)
total lipase(LA) in serum of the rats were observered.Result:Wendan decoction reduced the levels of TC
TG of the modal rats
compared with the model group the differences are P<0.01 and P<0.05.Wendan decoction raised SOD and reduced MDA
P<0.05 and P<0.01.At the same time
Wendan decoction could raise the activity of LA and LPL
P<0.01.but there was no effect on HL.Conclusion:Wendan decoction can regulate the disorder of lipid metabolism by raising the activity of LA and LPL in the modal rats effectively
and it may reduce the degree of lipid peroxidation and cell damage.