Relationship Between Traditional Medical Formulae and Syndrome Based Pharmacological Study of Xiayuxue Decoction against Porcine Serum Induced Liver Fibrosis in Rats
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Relationship Between Traditional Medical Formulae and Syndrome Based Pharmacological Study of Xiayuxue Decoction against Porcine Serum Induced Liver Fibrosis in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 6, Pages: 30-32(2007)
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Published:2007
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DU Guang-li, Liu Ping, WANG Lei, et al. Relationship Between Traditional Medical Formulae and Syndrome Based Pharmacological Study of Xiayuxue Decoction against Porcine Serum Induced Liver Fibrosis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(6): 30-32.
DOI:
DU Guang-li, Liu Ping, WANG Lei, et al. Relationship Between Traditional Medical Formulae and Syndrome Based Pharmacological Study of Xiayuxue Decoction against Porcine Serum Induced Liver Fibrosis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(6): 30-32.DOI:
Relationship Between Traditional Medical Formulae and Syndrome Based Pharmacological Study of Xiayuxue Decoction against Porcine Serum Induced Liver Fibrosis in Rats
Objective:To study relationship between traditional medical formulae and syndrome of Xiayuxue Decotion against liver fibrosis in rats induced by porcine serum.Methods:Liver fibrosis in rats was induced by intraperitoneal injection of porcine serum.10 rats(4 in normal group and 6 in model group)were sacrificed after 8 w of modelling.The rest rats were then devided into normal group
model group
Xiayuxue Decoction group
Yinchenhao Decoction group
Huangqi Dectoction group
Erzhi Pill Group and Xiaochaihu Decoction Group.Porcine serum was continuous given at the same time of administration.Rats were sacrificed and sample was obtained at the end of 12 w of modeling.ALT
AST
ALP and GGT activity
and Alb
TP and TBil content in rats were determined.Hyp content in rat liver tissue was assayed with hydrochloric acid hydrolyzing method
and histological changes with HE staining and collagen deposition with sirus red staining.Results:ALT and AST levels increased significantly(P<0.05)
Alb and TP content decrease markedly(P<0.05).For the increased ALP
GGT and TBil levels there are no.Compared with model rats the improved liver function of rats in treatment groups is found especially in Xiayuxue Decoction.Compared with normal group
Hyp content of liver tissue in modeling rats increased significantly(P<0.01).Compared with model group
liver tissue Hyp content in rats of Xiayuxue Decoction group decreases significantly(P<0.05)
Hyp content in Yinchenhao Decoction group also decreases to some extent without statistical significance(P>0.05).Conclusion:Xiayuxue Decoction effectively inhibits liver fibrosis in rats induced by porcine serum
which indicated that liver fibrosis induced by porcine serum in rats might be blood stasis congesting vessels.
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Related Author
TAN Shan-zhong
DU Guang-li
LIU Ping
WANG Lei
TAN Shan-zhong
LONG Ai-hua
MU Yong-ping
WANG Chun-shu
Related Institution
Shanghai University of TCM
Henan General Hospital
The First Affiliated Hospital of Henan University of Chinese Medicine
The First Clinical Medical College of Henan University of Chinese Medicine
The Healthcare Center for Shishan Street of Suzhou New District