Effect of Shukang Pingchuan Capsule on IFN-γ,IL-4,IL-5 and IFN-γ/IL-4 in Asthmatic Rats
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Effect of Shukang Pingchuan Capsule on IFN-γ,IL-4,IL-5 and IFN-γ/IL-4 in Asthmatic Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 1, Pages: 52-54(2007)
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Published:2007
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HAN Tao1, LAN Yong-mei2, AN Dong-qing3. Effect of Shukang Pingchuan Capsule on IFN-γ,IL-4,IL-5 and IFN-γ/IL-4 in Asthmatic Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(1): 52-54.
DOI:
HAN Tao1, LAN Yong-mei2, AN Dong-qing3. Effect of Shukang Pingchuan Capsule on IFN-γ,IL-4,IL-5 and IFN-γ/IL-4 in Asthmatic Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(1): 52-54.DOI:
Effect of Shukang Pingchuan Capsule on IFN-γ,IL-4,IL-5 and IFN-γ/IL-4 in Asthmatic Rats
Objective:To study the effects of Shukang Pingchuan Capsule(SKPCC) on IFN-γ
IL-4
IL-5 and IFN-γ/IL-4 in Asthmatic Rats.Methods:Rats are divided into 6 groups:normal control group
asthmatic model group
SKPCC with large
medium
and small dose group
and hormone(dexamethasone) group.Asthmatic model was established by sensitizing and challenging rats with OVA.The level of IFN-γ
IL-4 and IL-5 and the IFN-γ/IL-4 ratio in BALF was measured by ELISA.Results:The IFN-γ level was higher(P<0.05)
the IL-4 and IL-5 level significantly lower(P<0.01 orc P<0.05) in large and medium SKPCC treatment group compared with asthmatic model group.The IFN-γ/IL-4 ratio in SKPCC treatment group was significantly higher than that in asthmatic model group(P<0.01).Conclusion:SKPCC can adjust Th1/Th2 in asthmatic rats
inhibite the inflammation in trachea and lower its high reaction
which may be one of the mechanisms of SKPCC in treating asthma.