Study on the Antihyperlipidemia Effect of Allicin and the Mechanism
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Study on the Antihyperlipidemia Effect of Allicin and the Mechanism
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 2, Pages: 32-35(2007)
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Published:2007
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ZHANG Ting-ting1, TONG Xi-qiong2, LIU Xi-yun3. Study on the Antihyperlipidemia Effect of Allicin and the Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 32-35.
DOI:
ZHANG Ting-ting1, TONG Xi-qiong2, LIU Xi-yun3. Study on the Antihyperlipidemia Effect of Allicin and the Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 32-35.DOI:
Study on the Antihyperlipidemia Effect of Allicin and the Mechanism
Objective:To study the antihyperlipidemia effect of allicin and the mechanism.Methods:50 mice were divided into five groups:control group
hyperlipidmia
small
medium and large dose groups of allicin with hyperlipidemia.Levels of TG
TC
HDL-C
LDL-C
lecithin cholesterol acyltransferase(LCAT)
lipoprotein lipase of heart(LPL)
hepatic lipase(HL)and 3-hydroxy-3-methylglutaryl-CoA(HMGCoA) reductase were measured.The experiment on particle of cholesterol in vitro was performed.Results:Allicin has obvious effects of reducing the contents of TG
TC
LDL-C and increasing the content of HDL-C.Allicin can
to some extent
increase the activities of LCAT
LPL and HL
and decrease the activity of liver HMGCoA reductase in vitro.Allicin also can inhibit the particle of cholesterol in vitro.Conclusion:Allicin obviously decreased the blood lipids.The mechanisms of reducing blood lipids perhaps were to promote the metabolism and change of the lipoprotein
inhibit absorbing cholesterol and reduce cholesterol biosynthesis as well as enhance TG decomposition in the mice serum and liver.
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