Influences of the Chinese Prescription of Reinforcing the Kidney,Activating Blood Circulation and Resolving Phlegm on Brain Nurotransmitters and β-AP in Senile Dementia Model of Rat Induced by D-galactose
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Influences of the Chinese Prescription of Reinforcing the Kidney,Activating Blood Circulation and Resolving Phlegm on Brain Nurotransmitters and β-AP in Senile Dementia Model of Rat Induced by D-galactose
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 2, Pages: 42-45(2007)
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Published:2007
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XIONG Ping, JIANG Ling-zhi1, HUANG Zhao-sheng2. Influences of the Chinese Prescription of Reinforcing the Kidney,Activating Blood Circulation and Resolving Phlegm on Brain Nurotransmitters and β-AP in Senile Dementia Model of Rat Induced by D-galactose[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 42-45.
DOI:
XIONG Ping, JIANG Ling-zhi1, HUANG Zhao-sheng2. Influences of the Chinese Prescription of Reinforcing the Kidney,Activating Blood Circulation and Resolving Phlegm on Brain Nurotransmitters and β-AP in Senile Dementia Model of Rat Induced by D-galactose[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 42-45.DOI:
Influences of the Chinese Prescription of Reinforcing the Kidney,Activating Blood Circulation and Resolving Phlegm on Brain Nurotransmitters and β-AP in Senile Dementia Model of Rat Induced by D-galactose
Objective:To investigate the influences of the Chinese prescription of reinforcing the kidney
activating blood circulation and resolving phlegm on cerebral AchE and β-AP in senile dementia model of rat induced by D-galactose.Method:Senile dementia model of rat was established by intraperitoneal injection of D-galactose combined with injection of goose paste gill fungus amino acid(IBO) at bilateral Meynert basal nucleus.AchE and β-AP were determined by radio-immunological and histo-immunological techniques.Results:Compared with the model group
AchE in cerebral cortex was significantly increased in the large dose group of the Chinese prescription (P<0.01)
while the β-AP was decreased(P<0.05).Conclusion:The Chinese prescription may enhance AchE activity to restore the memory ability by reducing β-AP level.
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